Liposomal Circular Dichroism. Assignment of Remote Stereocenters in Plakinic Acids K and L from a Plakortis-Xestospongia Sponge Association

被引：23

作者：

Dalisay, Doralyn S. ^{[1
]}

Quach, Tim ^{[1
]}

Molinski, Tadeusz F. ^{[1
,2
]}

机构：

[1] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 07期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

ASCIDIAN STOLONICA-SOCIALIS; CYCLIC PEROXIDES; STEREOCHEMICAL ASSIGNMENT; ABSOLUTE STEREOCHEMISTRY; CONFIGURATION; STOLONOXIDES; METABOLITES;

D O I：

10.1021/ol100249v

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new omega-phenyl polyketide peroxides, plakinic acids K and L, were Isolated from a two-sponge association of Plakortis halichondroides and Xestospongia deweerdtae. The absolute configurations of the remote dimethyl-branched stereocenters in plakinic acid K were assigned by degradation of plakinic acid K to a long-chain naphthamide and analysis by liposomal circular dichroism (L-CD) and comparison with synthetic standards.

引用

页码：1524 / 1527

页数：4

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