Stereotactic Body Radiotherapy (SBRT) with Lower Doses for Selected Patients with Stage I Non-small-cell Lung Cancer (NSCLC)

被引：18

作者：

Janssen, Stefan ^{[1
,2
]}

Kaesmann, Lukas ^{[1
]}

Rudat, Volker ^{[3
]}

Rades, Dirk ^{[1
]}

机构：

[1] Med Univ Lubeck, Dept Radiat Oncol, Ratzeburger Allee 160, D-23538 Lubeck, Germany

[2] Med Practice Radiotherapy & Radiat Oncol, Hannover, Germany

[3] Saad Specialist Hosp, Dept Radiat Oncol, Al Khobar, Saudi Arabia

来源：

LUNG | 2016年 / 194卷 / 02期

关键词：

Non-small-cell lung cancer; Early stage; Stereotactic body radiotherapy; Biologically effective dose; Treatment results; HYPERFRACTIONATED RADIATION-THERAPY; OUTCOMES; I/II; SURVIVAL; SURGERY; IMPACT;

D O I：

10.1007/s00408-016-9849-4

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

SBRT is very effective for stage I NSCLC. Biologically effective doses (BED) > 100 Gy are recommended. Elderly patients and those with a limited performance status may not tolerate these high doses. This study investigated the outcomes after lower dose SBRT (BED < 90 Gy) in 46 patients with stage I NSCLC, who were aged a parts per thousand yen70 years or in reduced general condition. Local control rates at 1, 2, and 3 years were 100, 95, and 95 %, respectively. Rates of freedom from distant progression were 83, 63, and 54 %, and survival rates were 77, 57, and 36 %, respectively. Seventeen patients died during the follow-up, 11 (65 %) from distant progression of NSCLC, and six (35 %) from non-malignant causes. No patient developed radiation-induced pneumonitis. Thus, SBRT with BED < 90 Gy resulted in excellent local control and appears to be a reasonable option for stage I NSCLC in elderly patients and those with a poor performance status.

引用

页码：291 / 294

页数：4

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