RecQ helicases: Caretakers of the genome

被引：557

作者：

Hickson, ID ^{[1
]}

机构：

[1] Univ Oxford, John Radcliffe Hosp, Weatherall Inst Mol Med, Canc Res UK Labs, Oxford OX3 9DS, England

来源：

NATURE REVIEWS CANCER | 2003年 / 3卷 / 03期

关键词：

D O I：

10.1038/nrc1012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

RecQ helicases are highly conserved from bacteria to man. Germline mutations in three of the five known family members in humans give rise to debilitating disorders that are characterized by, amongst other things, a predisposition to the development of cancer. One of these disorders - Bloom's syndrome - is uniquely associated with a predisposition to cancers of all types. So how do RecQ helicases protect against cancer? They seem to maintain genomic stability by functioning at the interface between DNA replication and DNA repair.

引用

页码：169 / 178

页数：10

共 117 条

[21] THE BLOOMS-SYNDROME GENE-PRODUCT IS HOMOLOGOUS TO RECQ HELICASES [J].

ELLIS, NA ;

GRODEN, J ;

YE, TZ ;

STRAUGHEN, J ;

LENNON, DJ ;

CIOCCI, S ;

PROYTCHEVA, M ;

GERMAN, J .

CELL, 1995, 83 (04) :655-666

[22] DNA repair: The Nijmegen breakage syndrome protein [J].

Featherstone, C ;

Jackson, SP .

CURRENT BIOLOGY, 1998, 8 (17) :R622-R625

[23] Human Werner syndrome DNA helicase unwinds tetrahelical structures of the fragile X syndrome repeat sequence d(CGG)n [J].

Fry, M ;

Loeb, LA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (18) :12797-12802

[24] MUTATOR PHENOTYPE OF WERNER SYNDROME IS CHARACTERIZED BY EXTENSIVE DELETIONS [J].

FUKUCHI, K ;

MARTIN, GM ;

MONNAT, RJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (15) :5893-5897

[25] THE YEAST TYPE-I TOPOISOMERASE TOP3 INTERACTS WITH SGS1, A DNA HELICASE HOMOLOG - A POTENTIAL EUKARYOTIC REVERSE GYRASE [J].

GANGLOFF, S ;

MCDONALD, JP ;

BENDIXEN, C ;

ARTHUR, L ;

ROTHSTEIN, R .

MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (12) :8391-8398

[26]

Gao WM, 2002, GENETICS, V162, P103

[27] BLOOMS SYNDROME [J].

GERMAN, J .

DERMATOLOGIC CLINICS, 1995, 13 (01) :7-18

[28] Enhanced tumor formation in mice heterozygous for Blm mutation [J].

Goss, KH ;

Risinger, MA ;

Kordich, JJ ;

Sanz, MM ;

Straughen, JE ;

Slovek, LE ;

Capobianco, AJ ;

German, J ;

Boivin, GP ;

Groden, J .

SCIENCE, 2002, 297 (5589) :2051-2053

[29] Advances in library administration and organization, vol 15 [J].

Gray, CM .

JOURNAL OF ACADEMIC LIBRARIANSHIP, 1998, 24 (06) :487-488

[30] BLM heterozygosity and the risk of colorectal cancer [J].

Gruber, SB ;

Ellis, NA ;

Rennert, G ;

Offit, K .

SCIENCE, 2002, 297 (5589) :2013-2013

← 1 2 3 4 5 6 7 8 9 10 →