RecQ helicases: Caretakers of the genome

被引：557
作者：
Hickson, ID [1 ]
机构：
[1] Univ Oxford, John Radcliffe Hosp, Weatherall Inst Mol Med, Canc Res UK Labs, Oxford OX3 9DS, England
来源：
NATURE REVIEWS CANCER | 2003年 / 3卷 / 03期
关键词：
D O I：
10.1038/nrc1012
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
RecQ helicases are highly conserved from bacteria to man. Germline mutations in three of the five known family members in humans give rise to debilitating disorders that are characterized by, amongst other things, a predisposition to the development of cancer. One of these disorders - Bloom's syndrome - is uniquely associated with a predisposition to cancers of all types. So how do RecQ helicases protect against cancer? They seem to maintain genomic stability by functioning at the interface between DNA replication and DNA repair.
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页码：169 / 178
页数：10
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