Advanced nanomedicine and cancer: Challenges and opportunities in clinical translation

被引：86
作者：
Gonzalez-Valdivieso, Juan [1 ]
Girotti, Alessandra [2 ]
Schneider, Jose [1 ,3 ]
Javier Arias, Francisco [1 ]
机构：
[1] Univ Valladolid, Smart Biodevices NanoMed Grp, LUCIA Bldg, Valladolid 47011, Spain
[2] Univ Valladolid, CIBER BBN, BIOFORGE Res Grp, Grp Adv Mat & Nanobiotechnol, LUCIA Bldg, Valladolid 47011, Spain
[3] Univ Valladolid, Sch Med, Dept Obstet & Gynecol, Valladolid 47005, Spain
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2021年 / 599卷
关键词：
Cancer; Nanomedicine; Chemotherapy; Drug delivery; Nanodrugs; PEGYLATED LIPOSOMAL DOXORUBICIN; DRUG-DELIVERY SYSTEMS; PATIENT-DERIVED XENOGRAFTS; POLYMER-BASED NANOPARTICLE; CONJUGATED L-ASPARAGINASE; ADVANCED SOLID TUMORS; PHASE-I; TARGETED DELIVERY; SAFETY PROFILE; BREAST-CANCER;
D O I：
10.1016/j.ijpharm.2021.120438
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Cancer has reached pandemic dimensions in the whole world. Although current medicine offers multiple treatment options against cancer, novel therapeutic strategies are needed due to the low specificity of chemotherapeutic drugs, undesired side effects and the presence of different incurable types of cancer. Among these new strategies, nanomedicine arises as an encouraging approach towards personalized medicine with high potential for present and future cancer patients. Therefore, nanomedicine aims to develop novel tools with wide potential in cancer treatment, imaging or even theranostic purposes. Even though numerous preclinical studies have been published with successful preliminary results, promising nanosystems have to face multiple obstacles before adoption in clinical practice as safe options for patients with cancer. In this MiniReview, we provide a short overview on the latest advances in current nanomedicine approaches, challenges and promising strategies towards more accurate cancer treatment.
引用
收藏
页数：9
相关论文
共 131 条
[1]   Extracellular matrix-based biomaterial scaffolds and the host response [J].
Aamodt, Joseph M. ;
Grainger, David W. .
BIOMATERIALS, 2016, 86 :68-82
[2]   Weekly polyethylene glycol conjugated L-asparaginase compared with biweekly dosing produces superior induction remission rates in childhood relapsed acute lymphoblastic leukemia: a pediatric oncology group study [J].
Abshire, TC ;
Pollock, BH ;
Billett, AL ;
Bradley, P ;
Buchanan, GR .
BLOOD, 2000, 96 (05) :1709-1715
[3]   Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy [J].
Aggarwal, Parag ;
Hall, Jennifer B. ;
McLeland, Christopher B. ;
Dobrovolskaia, Marina A. ;
McNeil, Scott E. .
ADVANCED DRUG DELIVERY REVIEWS, 2009, 61 (06) :428-437
[4]   A phase I-II trial of polyethylene glycol-conjugated L-asparaginase in patients with multiple myeloma [J].
Agrawal, NR ;
Bukowski, RM ;
Rybicki, LA ;
Kurtzberg, J ;
Cohen, LJ ;
Hussein, MA .
CANCER, 2003, 98 (01) :94-99
[5]   Liposomal drug delivery systems: From concept to clinical applications [J].
Allen, Theresa M. ;
Cullis, Pieter R. .
ADVANCED DRUG DELIVERY REVIEWS, 2013, 65 (01) :36-48
[6]  
[Anonymous], 2012, J CONTR RELEASE, V160, P117, DOI [10.1016/j.jconrel.2012.03.020., DOI 10.1016/J.JCONREL.2012.03.020, 10.1016/J, DOI 10.1016/J]
[7]   Synthesis and characterization of PLGA nanoparticles [J].
Astete, Carlos E. ;
Sabliov, Cristina M. .
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 2006, 17 (03) :247-289
[8]   Doxil® - The first FDA-approved nano-drug: Lessons learned [J].
Barenholz, Yechezkel .
JOURNAL OF CONTROLLED RELEASE, 2012, 160 (02) :117-134
[9]   Cellular uptake of nanoparticles: journey inside the cell [J].
Behzadi, Shahed ;
Serpooshan, Vahid ;
Tao, Wei ;
Hamaly, Majd A. ;
Alkawareek, Mahmoud Y. ;
Dreaden, Erik C. ;
Brown, Dennis ;
Alkilany, Alaaldin M. ;
Farokhzad, Omid C. ;
Mahmoudi, Morteza .
CHEMICAL SOCIETY REVIEWS, 2017, 46 (14) :4218-4244
[10]   Biomaterials to model and measure epithelial cancers [J].
Beri, Pranjali ;
Matte, Bibiana F. ;
Fattet, Laurent ;
Kim, Daehwan ;
Yang, Jing ;
Engler, Adam J. .
NATURE REVIEWS MATERIALS, 2018, 3 (11) :418-430
12345678910