Epidermal growth factor receptor ligands: targets for optimizing treatment of metastatic colorectal cancer

被引：7

作者：

Foroughi, Siavash ^{[1
,2
]}

Tie, Jeanne ^{[1
,2
,3
,4
]}

Gibbs, Peter ^{[1
,2
,4
]}

Burgess, Antony Wilks ^{[1
,2
,5
]}

机构：

[1] Walter & Eliza Hall Inst Med Res, Personalised Oncol Div, 1G Royal Parade, Parkville, Vic 3052, Australia

[2] Univ Melbourne, Dept Med Biol, Parkville, Vic, Australia

[3] Peter MacCallum Canc Ctr, Dept Med Oncol, Melbourne, Australia

[4] Western Hlth, Dept Med Oncol, St Albans, Australia

[5] Univ Melbourne, Royal Melbourne Hosp, Dept Surg, Parkville, Vic, Australia

来源：

GROWTH FACTORS | 2019年 / 37卷 / 5-6期

关键词：

EGFR ligands; oncology; personalized therapy; metastatic colorectal cancer; INDEPENDENT PROGNOSTIC-FACTOR; CETUXIMAB PLUS IRINOTECAN; MESSENGER-RNA EXPRESSION; HUMAN-BREAST-CANCER; ANTI-EGFR THERAPY; PHASE-III TRIAL; MONOCLONAL-ANTIBODY; 1ST-LINE TREATMENT; GENE-EXPRESSION; RAS MUTATIONS;

D O I：

10.1080/08977194.2019.1703702

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The discovery of epidermal growth factor (EGF) and its receptor (EGFR) revealed the connection between EGF-like ligands, signaling from the EGFR family members and cancer. Over the next fifty years, analysis of EGFR expression and mutation led to the use of monoclonal antibodies to target EGFR in the treatment of metastatic colorectal cancer (mCRC) and this treatment has improved outcomes for patients. The use of the RAS oncogene mutational status has helped to refine patient selection for EGFR antibody therapy, but an effective molecular predictor of likely responders is lacking. This review analyzes the potential utility of measuring the expression, levels and activation of EGF-like ligands and associated processes as prognostic or predictive markers for the identification of patient risk and more effective mCRC therapies.

引用

页码：209 / 225

页数：17

共 150 条

[1] CELL-CELL ADHESION MEDIATED BY BINDING OF MEMBRANE-ANCHORED TRANSFORMING GROWTH FACTOR-ALPHA TO EPIDERMAL GROWTH-FACTOR RECEPTORS PROMOTES CELL-PROLIFERATION [J].