Relationship of Human Immunodeficiency Virus Viral Load in Cerebrospinal Fluid and Plasma in Patients Co-infected With Cryptococcal Meningitis

被引：10

作者：

Chang, Christina C. ^{[1
,2
,3
]}

Kangethe, Richard ^{[3
]}

Omarjee, Saleha ^{[3
]}

Hiramen, Keshni ^{[3
]}

Gosnell, Bernadett ^{[4
]}

Sojane, Katlego ^{[3
]}

Moosa, Mohamed-Yunus S. ^{[4
]}

Lewin, Sharon R. ^{[1
,2
,5
,6
]}

French, Martyn A. ^{[7
,8
,9
]}

Ndung'u, Thumbi ^{[3
,10
,11
,12
]}

机构：

[1] Alfred Hosp, Dept Infect Dis, Melbourne, Vic, Australia

[2] Monash Univ, Melbourne, Vic, Australia

[3] Univ KwaZulu Natal UKZN, Nelson R Mandela Sch Med, Doris Duke Med Res Inst, HIV Pathogenesis Programme, Durban, South Africa

[4] UKZN, King Edward VIII Hosp, Dept Infect Dis, Durban, South Africa

[5] Univ Melbourne, Peter Doherty Inst Infect & Immun, Melbourne, Vic, Australia

[6] Royal Melbourne Hosp, Melbourne, Vic, Australia

[7] Royal Perth Hosp, Dept Clin Immunol, Perth, WA, Australia

[8] PathWest Lab Med, Perth, WA, Australia

[9] Univ Western Australia, Sch Pathol & Lab Med, Perth, WA, Australia

[10] UKZN, Africa Hlth Res Inst, Nelson R Mandela Sch Med, Durban, South Africa

[11] Ragon Inst MGH MIT & Harvard Univ, Cambridge, MA USA

[12] Max Planck Inst Infect Biol, Charitepl, Berlin, Germany

来源：

OPEN FORUM INFECTIOUS DISEASES | 2017年 / 4卷 / 02期

基金：

澳大利亚国家健康与医学研究理事会; 新加坡国家研究基金会; 英国医学研究理事会;

关键词：

cerebrospinal fluid; cryptococcal meningitis; HIV; RECONSTITUTION INFLAMMATORY SYNDROME; CENTRAL-NERVOUS-SYSTEM; ANTIRETROVIRAL THERAPY; ESCAPE; EXPRESSION; BLOOD;

D O I：

10.1093/ofid/ofx032

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We measured human immunodeficiency virus (HIV) ribonucleic acid (RNA) in paired cerebrospinal fluid (CSF) and plasma samples in a prospective study of 91 HIV-infected, antiretroviral therapy-naive patients with cryptococcal meningitis. Cerebrospinal fluid HIV RNA was lower than in plasma (median 4.7 vs 5.2 log(10) copies/mL, P < .0001) and positively correlated with plasma HIV RNA, peripheral CD4(+) T-cell percentage, and CSF CXCL10. Plasma/CSF ratio of HIV RNA ranged widely from 0.2 to 265.5 with a median of 2.6. Cerebrospinal fluid quantitative cryptococcal culture positively correlated with CSF CCL2 and CCL3. CSF-plasma viral discordance was not associated with cryptococcal-associated immune reconstitution inflammatory syndrome.

引用

页数：5

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