Relationship of Human Immunodeficiency Virus Viral Load in Cerebrospinal Fluid and Plasma in Patients Co-infected With Cryptococcal Meningitis

被引：10
作者：
Chang, Christina C. [1 ,2 ,3 ]
Kangethe, Richard [3 ]
Omarjee, Saleha [3 ]
Hiramen, Keshni [3 ]
Gosnell, Bernadett [4 ]
Sojane, Katlego [3 ]
Moosa, Mohamed-Yunus S. [4 ]
Lewin, Sharon R. [1 ,2 ,5 ,6 ]
French, Martyn A. [7 ,8 ,9 ]
Ndung'u, Thumbi [3 ,10 ,11 ,12 ]
机构：
[1] Alfred Hosp, Dept Infect Dis, Melbourne, Vic, Australia
[2] Monash Univ, Melbourne, Vic, Australia
[3] Univ KwaZulu Natal UKZN, Nelson R Mandela Sch Med, Doris Duke Med Res Inst, HIV Pathogenesis Programme, Durban, South Africa
[4] UKZN, King Edward VIII Hosp, Dept Infect Dis, Durban, South Africa
[5] Univ Melbourne, Peter Doherty Inst Infect & Immun, Melbourne, Vic, Australia
[6] Royal Melbourne Hosp, Melbourne, Vic, Australia
[7] Royal Perth Hosp, Dept Clin Immunol, Perth, WA, Australia
[8] PathWest Lab Med, Perth, WA, Australia
[9] Univ Western Australia, Sch Pathol & Lab Med, Perth, WA, Australia
[10] UKZN, Africa Hlth Res Inst, Nelson R Mandela Sch Med, Durban, South Africa
[11] Ragon Inst MGH MIT & Harvard Univ, Cambridge, MA USA
[12] Max Planck Inst Infect Biol, Charitepl, Berlin, Germany
来源：
OPEN FORUM INFECTIOUS DISEASES | 2017年 / 4卷 / 02期
基金：
澳大利亚国家健康与医学研究理事会; 新加坡国家研究基金会; 英国医学研究理事会;
关键词：
cerebrospinal fluid; cryptococcal meningitis; HIV; RECONSTITUTION INFLAMMATORY SYNDROME; CENTRAL-NERVOUS-SYSTEM; ANTIRETROVIRAL THERAPY; ESCAPE; EXPRESSION; BLOOD;
D O I：
10.1093/ofid/ofx032
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We measured human immunodeficiency virus (HIV) ribonucleic acid (RNA) in paired cerebrospinal fluid (CSF) and plasma samples in a prospective study of 91 HIV-infected, antiretroviral therapy-naive patients with cryptococcal meningitis. Cerebrospinal fluid HIV RNA was lower than in plasma (median 4.7 vs 5.2 log(10) copies/mL, P < .0001) and positively correlated with plasma HIV RNA, peripheral CD4(+) T-cell percentage, and CSF CXCL10. Plasma/CSF ratio of HIV RNA ranged widely from 0.2 to 265.5 with a median of 2.6. Cerebrospinal fluid quantitative cryptococcal culture positively correlated with CSF CCL2 and CCL3. CSF-plasma viral discordance was not associated with cryptococcal-associated immune reconstitution inflammatory syndrome.
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页数：5
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