P2X4 receptor expression in a rat model of trigeminal neuropathic pain

被引：20
|
作者：
Nakai, Kunihiro [1 ]
Nakae, Aya [2 ]
Oba, Sosuke [1 ]
Mashimo, Takashi [2 ]
Ueda, Koichi [1 ]
机构：
[1] Osaka Med Coll, Dept Plast & Reconstruct Surg, Takatsuki, Osaka 5698686, Japan
[2] Osaka Univ, Grad Sch Med, Dept Anesthesiol & Intens Care Med, Osaka, Japan
来源：
NEUROREPORT | 2010年 / 21卷 / 08期
关键词：
ATF3; infraorbital nerve injury; macrophage invasion; neuropathic pain; P2X(4) receptor; serotonin selective reuptake inhibitor; POSSIBLE INVOLVEMENT; INFRAORBITAL NERVE; INJURY; ANTIDEPRESSANTS; DEGENERATION; MACROPHAGES;
D O I：
10.1097/WNR.0b013e32833980b2
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We investigated the P2X(4) receptor (P2X(4)R) expression in the cervical spinal cord, trigeminal ganglion, and infraorbital nerve (ION), after a chronic constriction injury of unilateral ION and a treatment with selective serotonin reuptake inhibitor (SSRI). A recent study has showed that SSRI inhibits P2X(4)R expression. Injured rats had significantly lower pain thresholds. In injured and slightly injured ION, the P2X(4)R expression was significantly higher than in the naive-rat ION. Injured animals with SSRI showed significantly higher pain thresholds than injured animals without the drug. Nonetheless, P2X(4)R expression in the ipsilateral ION remained high. Immunostaining showed that macrophages are the source of P2X(4)R. Our results suggest that the expression of P2X(4)R in our model is modulated not by neuropathic pain, but by slight nerve injury. NeuroReport 21:559-563 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
引用
收藏
页码：559 / 563
页数：5
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