Targeting tumor-associated macrophages in cancer therapy and understanding their complexity

被引：26

作者：

Cannarile, Michael A. ^{[1
]}

Ries, Carola H. ^{[1
]}

Hoves, Sabine ^{[1
]}

Ruettinger, Dominik ^{[1
]}

机构：

[1] Roche Innovat Ctr Penzberg, Roche Pharmaceut Res & Early Dev, Discovery Oncol, Penzberg, Germany

来源：

ONCOIMMUNOLOGY | 2014年 / 3卷 / 09期

关键词：

tumor-associated macrophages; CSF-1R; RG7155; TAM depletion; myeloid cells;

D O I：

10.4161/21624011.2014.955356

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Macrophage infiltration has been identified as an independent, poor prognostic factor for patients afflicted with various cancer entities. However, the characterization of tumor-associated macrophages (TAMs) prior to and following cancer patient treatment has been limited. Our study analyzed tumor biopsies before and after anti-CSF-1R antibody treatment unraveling the nature of TAMs and providing novel insights into their phenotypic and functional characteristics in cancer.

引用

页数：2

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