miRNAs: Critical mediators of breast cancer metastatic programming

被引：11
作者：
Nair, Madhumathy G. [1 ]
Somashekaraiah, Vidya M. [1 ]
Ramamurthy, Vishakha [1 ]
Prabhu, Jyothi S. [1 ]
Sridhar, T. S. [1 ]
机构：
[1] St Johns Res Inst, Div Mol Med, Bangalore, Karnataka, India
来源：
EXPERIMENTAL CELL RESEARCH | 2021年 / 401卷 / 01期
关键词：
microRNAs; Breast cancer; Metastasis; Tumor microenvironment; Metastatic organotropism; EPITHELIAL-MESENCHYMAL TRANSITION; POLARITY PROTEIN PAR6; LYMPH-NODE METASTASIS; CELL-MIGRATION; E-CADHERIN; DOWN-REGULATION; MATRIX-METALLOPROTEINASE; INHIBITS PROLIFERATION; TUMOR-SUPPRESSOR; CIRCULATING MIRNAS;
D O I：
10.1016/j.yexcr.2021.112518
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
MicroRNA mediated aberrant gene regulation has been implicated in several diseases including cancer. Recent research has highlighted the role of epigenetic modulation of the complex process of breast cancer metastasis by miRNAs. miRNAs play a crucial role in the process of metastatic evolution by facilitating alterations in the phenotype of tumor cells and the tumor microenvironment that promote this process. They act as critical determinants of the multi-step progression starting from carcinogenesis all the way to organotropism. In this review, we focus on the current understanding of the compelling role of miRNAs in breast cancer metastasis.
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页数：16
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