miRNAs: Critical mediators of breast cancer metastatic programming

被引：11
作者：
Nair, Madhumathy G. [1 ]
Somashekaraiah, Vidya M. [1 ]
Ramamurthy, Vishakha [1 ]
Prabhu, Jyothi S. [1 ]
Sridhar, T. S. [1 ]
机构：
[1] St Johns Res Inst, Div Mol Med, Bangalore, Karnataka, India
来源：
EXPERIMENTAL CELL RESEARCH | 2021年 / 401卷 / 01期
关键词：
microRNAs; Breast cancer; Metastasis; Tumor microenvironment; Metastatic organotropism; EPITHELIAL-MESENCHYMAL TRANSITION; POLARITY PROTEIN PAR6; LYMPH-NODE METASTASIS; CELL-MIGRATION; E-CADHERIN; DOWN-REGULATION; MATRIX-METALLOPROTEINASE; INHIBITS PROLIFERATION; TUMOR-SUPPRESSOR; CIRCULATING MIRNAS;
D O I：
10.1016/j.yexcr.2021.112518
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
MicroRNA mediated aberrant gene regulation has been implicated in several diseases including cancer. Recent research has highlighted the role of epigenetic modulation of the complex process of breast cancer metastasis by miRNAs. miRNAs play a crucial role in the process of metastatic evolution by facilitating alterations in the phenotype of tumor cells and the tumor microenvironment that promote this process. They act as critical determinants of the multi-step progression starting from carcinogenesis all the way to organotropism. In this review, we focus on the current understanding of the compelling role of miRNAs in breast cancer metastasis.
引用
收藏
页数：16
相关论文
共 248 条
  • [111] The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2
    Korpal, Manav
    Lee, Esther S.
    Hu, Guohong
    Kang, Yibin
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (22) : 14910 - 14914
  • [112] Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization
    Korpal, Manav
    Ell, Brian J.
    Buffa, Francesca M.
    Ibrahim, Toni
    Blanco, Mario A.
    Celia-Terrassa, Toni
    Mercatali, Laura
    Khan, Zia
    Goodarzi, Hani
    Hua, Yuling
    Wei, Yong
    Hu, Guohong
    Garcia, Benjamin A.
    Ragoussis, Jiannis
    Amadori, Dino
    Harris, Adrian L.
    Kang, Yibin
    [J]. NATURE MEDICINE, 2011, 17 (09) : 1101 - U108
  • [113] MicroRNA-18a inhibits hypoxia-inducible factor 1α activity and lung metastasis in basal breast cancers
    Krutilina, Raisa
    Sun, Wenlin
    Sethuraman, Aarti
    Brown, Martin
    Seagroves, Tiffany N.
    Pfeffer, Lawrence M.
    Ignatova, Tatyana
    Fan, Meiyun
    [J]. BREAST CANCER RESEARCH, 2014, 16 (04):
  • [114] miRNA proxy approach reveals hidden functions of glycosylation
    Kurcon, Tomasz
    Liu, Zhongyin
    Paradkar, Anika V.
    Vaiana, Christopher A.
    Koppolu, Sujeethraj
    Agrawal, Praveen
    Mahal, Lara K.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (23) : 7327 - 7332
  • [115] Selectins promote tumor metastasis
    Laeubli, Heinz
    Borsig, Lubor
    [J]. SEMINARS IN CANCER BIOLOGY, 2010, 20 (03) : 169 - 177
  • [116] miR-203 and miR-320 Regulate Bone Morphogenetic Protein-2-Induced Osteoblast Differentiation by Targeting Distal-Less Homeobox 5 (Dlx5)
    Laxman, Navya
    Mallmin, Hans
    Nilsson, Olle
    Kindmark, Andreas
    [J]. GENES, 2017, 8 (01)
  • [117] miR-200-containing extracellular vesicles promote breast cancer cell metastasis
    Le, Minh T. N.
    Hamar, Peter
    Guo, Changying
    Basar, Emre
    Perdigao-Henriques, Ricardo
    Balaj, Leonora
    Lieberman, Judy
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2014, 124 (12) : 5109 - 5128
  • [118] Pax-5 Inhibits Breast Cancer Proliferation Through MiR-215 Up-regulation
    Leblanc, Nicolas
    Harquail, Jason
    Crapoulet, Nicolas
    Ouellette, Rodney J.
    Robichaud, Gilles A.
    [J]. ANTICANCER RESEARCH, 2018, 38 (09) : 5013 - 5026
  • [119] Lee AHS, 1998, J PATHOL, V185, P394, DOI 10.1002/(SICI)1096-9896(199808)185:4<394::AID-PATH117>3.0.CO
  • [120] 2-S
78910111213141516