miRNAs: Critical mediators of breast cancer metastatic programming

被引：11
作者：
Nair, Madhumathy G. [1 ]
Somashekaraiah, Vidya M. [1 ]
Ramamurthy, Vishakha [1 ]
Prabhu, Jyothi S. [1 ]
Sridhar, T. S. [1 ]
机构：
[1] St Johns Res Inst, Div Mol Med, Bangalore, Karnataka, India
来源：
EXPERIMENTAL CELL RESEARCH | 2021年 / 401卷 / 01期
关键词：
microRNAs; Breast cancer; Metastasis; Tumor microenvironment; Metastatic organotropism; EPITHELIAL-MESENCHYMAL TRANSITION; POLARITY PROTEIN PAR6; LYMPH-NODE METASTASIS; CELL-MIGRATION; E-CADHERIN; DOWN-REGULATION; MATRIX-METALLOPROTEINASE; INHIBITS PROLIFERATION; TUMOR-SUPPRESSOR; CIRCULATING MIRNAS;
D O I：
10.1016/j.yexcr.2021.112518
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
MicroRNA mediated aberrant gene regulation has been implicated in several diseases including cancer. Recent research has highlighted the role of epigenetic modulation of the complex process of breast cancer metastasis by miRNAs. miRNAs play a crucial role in the process of metastatic evolution by facilitating alterations in the phenotype of tumor cells and the tumor microenvironment that promote this process. They act as critical determinants of the multi-step progression starting from carcinogenesis all the way to organotropism. In this review, we focus on the current understanding of the compelling role of miRNAs in breast cancer metastasis.
引用
收藏
页数：16
相关论文
共 248 条
  • [1] miR-34a Silences c-SRC to Attenuate Tumor Growth in Triple-Negative Breast Cancer
    Adams, Brian D.
    Wali, Vikram B.
    Cheng, Christopher J.
    Inukai, Sachi
    Booth, Carmen J.
    Agarwal, Seema
    Rimm, David L.
    Gyorffy, Balazs
    Santarpia, Libero
    Pusztai, Lajos
    Saltzman, W. Mark
    Slack, Frank J.
    [J]. CANCER RESEARCH, 2016, 76 (04) : 927 - 939
  • [2] ITGA2 promotes expression of ACLY and CCND1 in enhancing breast cancer stemness and metastasis
    Adorno-Cruz, Valery
    Hoffmann, Andrew D.
    Liu, Xia
    Dashzeveg, Nurmaa K.
    Taftaf, Rokana
    Wray, Brian
    Keri, Ruth A.
    Liu, Huiping
    [J]. GENES & DISEASES, 2021, 8 (04) : 493 - 508
  • [3] Differential cadherin expression: Potential markers for epithelial to mesenchymal transformation during tumor progression
    Agiostratidou, Georgia
    Hulit, James
    Phillips, Greg R.
    Hazan, Rachel B.
    [J]. JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA, 2007, 12 (2-3) : 127 - 133
  • [4] The transcription factor ZEB1 (δEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity
    Aigner, K.
    Dampier, B.
    Descovich, L.
    Mikula, M.
    Sultan, A.
    Schreiber, M.
    Mikulits, W.
    Brabletz, T.
    Strand, D.
    Obrist, P.
    Sommergruber, W.
    Schweifer, N.
    Wernitznig, A.
    Beug, H.
    Foisner, R.
    Eger, A.
    [J]. ONCOGENE, 2007, 26 (49) : 6979 - 6988
  • [5] Integrin endosomal signalling suppresses anoikis
    Alanko, Jonna
    Mai, Anja
    Jacquemet, Guillaume
    Schauer, Kristine
    Kaukonen, Riina
    Saari, Markku
    Goud, Bruno
    Ivaska, Johanna
    [J]. NATURE CELL BIOLOGY, 2015, 17 (11) : 1412 - 1421
  • [6] Alhasan Layla, 2019, Asian Pac J Cancer Prev, V20, P193
  • [7] High Serum miR-19a Levels Are Associated with Inflammatory Breast Cancer and Are Predictive of Favorable Clinical Outcome in Patients with Metastatic HER2+ Inflammatory Breast Cancer
    Anfossi, Simone
    Giordano, Antonio
    Gao, Hui
    Cohen, Evan N.
    Tin, Sanda
    Wu, Qiong
    Garza, Raul J.
    Debeb, Bisrat G.
    Alvarez, Ricardo H.
    Valero, Vicente
    Hortobagyi, Gabriel N.
    Calin, George A.
    Ueno, Naoto T.
    Woodward, Wendy A.
    Reuben, James M.
    [J]. PLOS ONE, 2014, 9 (01):
  • [8] Circulating miR-200c and miR-141 and outcomes in patients with breast cancer
    Antolin, Silvia
    Calvo, Lourdes
    Blanco-Calvo, Moises
    Paz Santiago, Maria
    Jose Lorenzo-Patino, Maria
    Haz-Conde, Mar
    Santamarina, Isabel
    Figueroa, Angelica
    Miguel Anton-Aparicio, Luis
    Valladares-Ayerbes, Manuel
    [J]. BMC CANCER, 2015, 15
  • [9] Par6-aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control
    Aranda, Victoria
    Haire, Teresa
    Nolan, Marissa E.
    Calarco, Joseph P.
    Rosenberg, Avi Z.
    Fawcett, James P.
    Pawson, Tony
    Muthuswamy, Senthil K.
    [J]. NATURE CELL BIOLOGY, 2006, 8 (11) : 1235 - U20
  • [10] Dynamic interactions of cortactin and membrane type 1 matrix metalloproteinase at invadopodia: Defining the stages of invadopodia formation and function
    Artym, VV
    Zhang, Y
    Seillier-Moiseiwitsch, FO
    Yamada, KM
    Mueller, SC
    [J]. CANCER RESEARCH, 2006, 66 (06) : 3034 - 3043
12345678910