Mesiotemporal atrophy and hippocampal diffusivity distinguish amnestic from non-amnestic vascular cognitive impairment

被引：12
作者：
Hosseini, A. A. [1 ,2 ]
Meng, D. [1 ,2 ]
Simpson, R. J. [1 ,2 ]
Auer, D. P. [1 ,2 ]
机构：
[1] Univ Nottingham, Sch Med, Sir Peter Mansfield Imaging Ctr, Nottingham, England
[2] Univ Nottingham, Div Clin Neurosci, Radiol Sci, Room WB 1441,B Floor,West Block,QMC Campus, Nottingham NG7 2UH, England
来源：
EUROPEAN JOURNAL OF NEUROLOGY | 2017年 / 24卷 / 07期
基金：
美国国家卫生研究院;
关键词：
hippocampus; magnetic resonance imaging; mild cognitive impairment; stroke; vascular dementia; CAROTID-ARTERY-DISEASE; ALZHEIMERS-DISEASE; MEAN DIFFUSIVITY; EXECUTIVE DYSFUNCTION; ELDERLY INDIVIDUALS; RISK-FACTORS; DEMENTIA; MATTER; STROKE; MEMORY;
D O I：
10.1111/ene.13299
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background and purpose: The role of clinical factors, cerebral infarcts and hippocampal damage in vascular cognitive impairment (VCI) subtypes remains unclear. Methods: Non-demented patients with carotid stenosis and recent transient ischemic attack/stroke had cognitive assessment and brain magnetic resonance imaging (MRI). Amnestic VCI was defined as memory impairment; non-amnestic VCI was any other subdomain impairment. Associations of MRI metrics [log-transformed total ischemic lesion load (log TILL), mesiotemporal atrophy (MTA) score, hippocampal mean diffusivity (hipMD)] with cognitive performance were assessed. Results: A hundred and eight patients, 47 with amnestic VCI and 21 with non-amnestic VCI, were assessed. A higher MTA (odds ratio 12.89, P = 0.001) and left hipMD (odds ratio 4.43, P = 0.003) contributed to amnestic VCI versus normal. Age-adjusted fluency correlated with log TILL (P = 0.002). Age-adjusted memory was associated with left hipMD (P = 0.001), MTA (P < 0.001) but not log TILL (P = 0.14). Left hipMD, MTA and smoking showed classification potential between amnestic VCI versus normal (area 0.859, P < 0.001). Conclusions: Neuroimaging assists stratification in amnestic VCI characterized by hippocampal changes and in non-amnestic VCI by higher ischemic burden. MTA and hippocampal diffusivity show diagnostic biomarker potential.
引用
收藏
页码：902 / 911
页数：10
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