From imaging to biology of glioblastoma: new clinical oncology perspectives to the problem of local recurrence

被引:9
作者
Zygogianni, A. [1 ]
Protopapa, M. [1 ]
Kougioumtzopoulou, A. [2 ]
Simopoulou, F. [1 ]
Nikoloudi, S. [1 ]
Kouloulias, V. [2 ]
机构
[1] Natl & Kapodistrian Univ Athens, Aretaie Univ Hosp, Med Sch, Radiotherapy Unit,Dept Radiol 1, Athens, Greece
[2] Natl & Kapodistrian Univ Athens, ATTIKON Univ Hosp, Med Sch, Radiotherapy Unit,Dept Radiol 2, Rimini 1, Chaidari 12462, Greece
关键词
Glioblastoma multiforme; Radiotherapy; Recurrence; Re-irradiation; Review; NEWLY-DIAGNOSED GLIOBLASTOMA; RANDOMIZED PHASE-III; MGMT PROMOTER METHYLATION; NEUTRON-CAPTURE THERAPY; HIGH-GRADE GLIOMAS; FRACTIONATED STEREOTACTIC RADIOTHERAPY; RECURSIVE PARTITIONING ANALYSIS; INTEGRATED GENOMIC ANALYSIS; CENTRAL-NERVOUS-SYSTEM; RADIATION-THERAPY;
D O I
10.1007/s12094-018-1831-6
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
GBM is one of the most common and aggressive brain tumors. Surgery and adjuvant chemoradiation have succeeded in providing a survival benefit. Although most patients will eventually experience local recurrence, the means to fight recurrence are limited and prognosis remains poor. In a disease where local control remains the major challenge, few trials have addressed the efficacy of local treatments, either surgery or radiation therapy. The present article reviews recent advances in the biology, imaging and biomarker science of GBM as well as the current treatment status of GBM, providing new perspectives to the problem of local recurrence.
引用
收藏
页码:989 / 1003
页数:15
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