Role of Oleic Acid in the Gut-Liver Axis: From Diet to the Regulation of Its Synthesis via Stearoyl-CoA Desaturase 1 (SCD1)

被引：94
作者：
Piccinin, Elena [1 ]
Cariello, Marica [1 ]
De Santis, Stefania [1 ,2 ,3 ]
Ducheix, Simon [4 ]
Sabba, Carlo [1 ]
Ntambi, James M. [5 ,6 ]
Moschetta, Antonio [1 ,2 ,7 ]
机构：
[1] Univ Bari Aldo Moro, Dept Interdisciplinary Med, Clin Med Cesare Frugoni, I-70124 Bari, Italy
[2] Natl Inst Biostruct & Biosyst, INBB, I-00136 Rome, Italy
[3] Univ Bari Aldo Moro, Dept Pharm Drug Sci, I-70126 Bari, Italy
[4] Univ Nantes, CNRS, INSERM, Inst Thorax, F-44007 Nantes, France
[5] Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA
[6] Univ Wisconsin, Dept Nutr Sci, Madison, WI 53706 USA
[7] IRCCS Ist Tumori Giovanni Paolo II, I-70124 Bari, Italy
来源：
NUTRIENTS | 2019年 / 11卷 / 10期
关键词：
olive oil; oleic acid; MUFA; stearoyl-CoA desaturase; liver; gut; POLYUNSATURATED FATTY-ACIDS; DEFICIENCY PROTECTS MICE; FISH-OIL SUPPLEMENTATION; PLURIPOTENT STEM-CELLS; COENZYME-A DESATURASE; VIRGIN OLIVE OIL; CARDIOVASCULAR-DISEASE; SCD1-DEFICIENT MICE; INSULIN-RESISTANCE; GENE-EXPRESSION;
D O I：
10.3390/nu11102283
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
The consumption of an olive oil rich diet has been associated with the diminished incidence of cardiovascular disease and cancer. Several studies have attributed these beneficial effects to oleic acid (C18 n-9), the predominant fatty acid principal component of olive oil. Oleic acid is not an essential fatty acid since it can be endogenously synthesized in humans. Stearoyl-CoA desaturase 1 (SCD1) is the enzyme responsible for oleic acid production and, more generally, for the synthesis of monounsaturated fatty acids (MUFA). The saturated to monounsaturated fatty acid ratio affects the regulation of cell growth and differentiation, and alteration in this ratio has been implicated in a variety of diseases, such as liver dysfunction and intestinal inflammation. In this review, we discuss our current understanding of the impact of gene-nutrient interactions in liver and gut diseases, by taking advantage of the role of SCD1 and its product oleic acid in the modulation of different hepatic and intestinal metabolic pathways.
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页数：22
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