3-(3,4-Dimethoxyphenyl)-5-(2-fluorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole

被引：4

作者：

Zamri, Adel ^{[1
]}

Teruna, Hilwan Y. ^{[1
]}

Wulansari, Sri ^{[1
]}

Herfindo, Noval ^{[1
]}

Frimayanti, Neni ^{[2
]}

Ikhtiarudin, Ihsan ^{[2
]}

机构：

[1] Univ Riau, Fac Math & Nat Sci, Dept Chem, Jalan HR Subrantas KM 12-5, Pekanbaru 28293, Indonesia

[2] Sekolah Tinggi Ilmu Farm STIFAR Riau, Dept Pharm, Jalan Kamboja, Pekanbaru 28293, Indonesia

来源：

MOLBANK | 2019年 / 2019卷 / 04期

关键词：

fluorinated pyrazolines; in silico study; sealed-vessel reactor; Monowave; 50; one-pot three-component reaction; DEN2; NS2B/NS3; protease; PYRAZOLINES; DERIVATIVES; DESIGN;

D O I：

10.3390/M1088

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new analogue of fluorinated pyrazoline (compound 1) has been synthesized via one-pot three-component reaction in a sealed-vessel reactor, Monowave 50. The structure of compound 1 has been established by spectroscopy analysis, including UV, FT-IR, HRMS, H-1 and C-13 NMR spectroscopy. Based on the in silico studies, this compound showed a good potential as an inhibitor for dengue virus type 2 (DEN2) NS2B/NS3 serine protease and can be used as a reference in the next design of an antidengue virus.

引用

页数：8

共 23 条

[1] Zinc-catalyzed synthesis of pyrazolines and pyrazoles via hydrohydrazination [J].