Role of Bacillus subtilis SpoIIIE in DNA transport across the mother cell-prespore division septum

被引：153
作者：
Bath, J
Wu, LJ
Errington, J
Wang, JC [1 ]
机构：
[1] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA
[2] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England
来源：
SCIENCE | 2000年 / 290卷 / 5493期
关键词：
D O I：
10.1126/science.290.5493.995
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The SpoIIIE protein of Bacillus subtilis is required for chromosome segregation during spore formation. The COOH-terminal cytoplasmic part of SpoIIIE was shown to be a DNA-dependent adenosine triphosphatase (ATPase) capable of tracking along DNA in the presence of ATP, and the NH2-terminal part of the protein was found to mediate its Localization to the division septum. Thus, during sporulation, SpoIIIE appears to act as a DNA pump that actively moves one of the replicated pair of chromosomes into the prespore. The presence of SpoIIIE homologs in a broad range of bacteria suggests that this mechanism for active transport of DNA may be widespread.
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页码：995 / 997
页数：3
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