LncRNA SNHG7 is an Oncogenic Biomarker Interacting with MicroRNA-193b in Colon Carcinogenesis

被引：14
作者：
Liu, K. L. [1 ]
Wu, J. [1 ]
Li, W. K. [1 ]
Li, N. S. [1 ]
Li, Q. [1 ]
Lao, Y. Q. [1 ]
机构：
[1] Capital Med Univ, Beijing Shijitan Hosp, Dept Gastroenterol, Yangfangdian 10, Beijing 100038, Peoples R China
来源：
CLINICAL LABORATORY | 2019年 / 65卷 / 11期
关键词：
SNHG7; colon cancer; miR-193b; lncRNA; CANCER; PROMOTES; PROLIFERATION; PROGRESSION; INHIBITION;
D O I：
10.7754/Clin.Lab.2019.190501
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Background: The expression and significance of small nucleolar RNA host gene 7 (SNHG7) in early-stage colon carcinogenesis remains unclear. Methods: The level of SNHG7 and microRNA-193b (miR-193b) was detected by qRT-PCR in colon tumor tissues and cells. The interaction of SNHG7 and miR-193b and the influence of SNHG7 silencing on colon tumor cells was evaluated. Results: Stepwise upregulated SNHG7 in colon advanced adenomas and early-stage cancer negatively correlates with miR-193b level, the direct interaction was confirmed in vitro. SNHG7 silencing in HT29 cells decreased proliferation and promoted apoptosis by inhibiting K-ras/ERK/cyclinD1. Conclusions: SNHG7 is an oncogenic biomarker in colon carcinogenesis. The effect may be mediated by interaction with miR-193b.
引用
收藏
页码：2199 / 2204
页数：6
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