LncRNA SNHG7 is an Oncogenic Biomarker Interacting with MicroRNA-193b in Colon Carcinogenesis

被引：14

作者：

Liu, K. L. ^{[1
]}

Wu, J. ^{[1
]}

Li, W. K. ^{[1
]}

Li, N. S. ^{[1
]}

Li, Q. ^{[1
]}

Lao, Y. Q. ^{[1
]}

机构：

[1] Capital Med Univ, Beijing Shijitan Hosp, Dept Gastroenterol, Yangfangdian 10, Beijing 100038, Peoples R China

来源：

CLINICAL LABORATORY | 2019年 / 65卷 / 11期

关键词：

SNHG7; colon cancer; miR-193b; lncRNA; CANCER; PROMOTES; PROLIFERATION; PROGRESSION; INHIBITION;

D O I：

10.7754/Clin.Lab.2019.190501

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Background: The expression and significance of small nucleolar RNA host gene 7 (SNHG7) in early-stage colon carcinogenesis remains unclear. Methods: The level of SNHG7 and microRNA-193b (miR-193b) was detected by qRT-PCR in colon tumor tissues and cells. The interaction of SNHG7 and miR-193b and the influence of SNHG7 silencing on colon tumor cells was evaluated. Results: Stepwise upregulated SNHG7 in colon advanced adenomas and early-stage cancer negatively correlates with miR-193b level, the direct interaction was confirmed in vitro. SNHG7 silencing in HT29 cells decreased proliferation and promoted apoptosis by inhibiting K-ras/ERK/cyclinD1. Conclusions: SNHG7 is an oncogenic biomarker in colon carcinogenesis. The effect may be mediated by interaction with miR-193b.

引用

页码：2199 / 2204

页数：6

共 16 条

[1] Colorectal cancer [J].

Brenner, Hermann ;

Kloor, Matthias ;

Pox, Christian Peter .

LANCET, 2014, 383 (9927) :1490-1502

[2] RETRACTED: LncRNA SNHG7 promotes pancreatic cancer proliferation through ID4 by sponging miR-342-3p (Retracted Article) [J].

Cheng, Dongfeng ;

Fan, Juanjuan ;

Ma, Yang ;

Zhou, Yiran ;

Qin, Kai ;

Shi, Minmin ;

Yang, Jingrui .

CELL AND BIOSCIENCE, 2019, 9 (1)

[3] Long Noncoding RNA SNHG7 Promotes the Tumor Growth and Epithelial-to-Mesenchymal Transition via Regulation of miR-34a Signals in Osteosarcoma [J].

Deng, Yiqi ;

Zhao, Feng ;

Zhang, Zhenhua ;

Sun, Fujie ;

Wang, Mingxing .

CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS, 2018, 33 (09) :365-372

[4] Deregulation of the MiR-193b-KRAS Axis Contributes to Impaired Cell Growth in Pancreatic Cancer [J].

Jin, Xianglan ;

Sun, Yang ;

Yang, Haiyan ;

Li, Ji ;

Yu, Shuangni ;

Chang, Xiaoyan ;

Lu, Zhaohui ;

Chen, Jie .

PLOS ONE, 2015, 10 (04)

[5] Long non-coding RNA-SNHG7 acts as a target of miR-34a to increase GALNT7 leve and regulate PI3K/Akt/mTOR pathway in colorectal cancer progression [J].

Li, Yang ;

Zeng, Changqian ;

Hu, Jialei ;

Pan, Yue ;

Shan, Yujia ;

Liu, Bing ;

Jia, Li .

JOURNAL OF HEMATOLOGY & ONCOLOGY, 2018, 11

[6] A Preliminary Study of the Value of Plasma microRNA-193b and Soluble Urokinase-Type Plasminogen Activator Receptor in Identifying Patients with Early-Stage Colorectal Cancer and Advanced Adenoma [J].

Liu, K. L. ;

Luo, J. L. ;

Wu, J. ;

Wang, Y. D. ;

Fan, H. J. .

CLINICAL LABORATORY, 2017, 63 (11-12) :1949-1953

[7]

Luo X, 2018, EUR REV MED PHARMACO, V22, P7788, DOI 10.26355/eurrev_201811_16403

[8] CCAT1 and CCAT2 long noncoding RNAs, located within the 8q. 24.21 'gene desert', serve as important prognostic biomarkers in colorectal cancer [J].

Ozawa, T. ;

Matsuyama, T. ;

Toiyama, Y. ;

Takahashi, N. ;

Ishikawa, T. ;

Uetake, H. ;

Yamada, Y. ;

Kusunoki, M. ;

Calin, G. ;

Goel, A. .

ANNALS OF ONCOLOGY, 2017, 28 (08) :1882-1888

[9] Long noncoding RNA SNHG7 accelerates prostate cancer proliferation and cycle progression through cyclin D1 by sponging miR-503 [J].

Qi, Honggang ;

Wen, Bifeng ;

Wu, Qihang ;

Cheng, Wei ;

Lou, Jiangyong ;

Wei, Junjun ;

Huang, Jianjun ;

Yao, Xuping ;

Weng, Guobin .

BIOMEDICINE & PHARMACOTHERAPY, 2018, 102 :326-332

[10] Long noncoding RNA SNHG7 promotes the progression and growth of glioblastoma via inhibition of miR-5095 [J].

Ren, Jie ;

Yang, Yong ;

Xue, Jun ;

Xi, Zhiyu ;

Hu, Liangyun ;

Pan, Si-Jian ;

Sun, Qingfang .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 496 (02) :712-718

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