LncRNA SNHG7 is an Oncogenic Biomarker Interacting with MicroRNA-193b in Colon Carcinogenesis

被引：14

作者：

Liu, K. L. ^{[1
]}

Wu, J. ^{[1
]}

Li, W. K. ^{[1
]}

Li, N. S. ^{[1
]}

Li, Q. ^{[1
]}

Lao, Y. Q. ^{[1
]}

机构：

[1] Capital Med Univ, Beijing Shijitan Hosp, Dept Gastroenterol, Yangfangdian 10, Beijing 100038, Peoples R China

来源：

CLINICAL LABORATORY | 2019年 / 65卷 / 11期

关键词：

SNHG7; colon cancer; miR-193b; lncRNA; CANCER; PROMOTES; PROLIFERATION; PROGRESSION; INHIBITION;

D O I：

10.7754/Clin.Lab.2019.190501

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Background: The expression and significance of small nucleolar RNA host gene 7 (SNHG7) in early-stage colon carcinogenesis remains unclear. Methods: The level of SNHG7 and microRNA-193b (miR-193b) was detected by qRT-PCR in colon tumor tissues and cells. The interaction of SNHG7 and miR-193b and the influence of SNHG7 silencing on colon tumor cells was evaluated. Results: Stepwise upregulated SNHG7 in colon advanced adenomas and early-stage cancer negatively correlates with miR-193b level, the direct interaction was confirmed in vitro. SNHG7 silencing in HT29 cells decreased proliferation and promoted apoptosis by inhibiting K-ras/ERK/cyclinD1. Conclusions: SNHG7 is an oncogenic biomarker in colon carcinogenesis. The effect may be mediated by interaction with miR-193b.

引用

页码：2199 / 2204

页数：6

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