Diverse roles of Eph receptors and ephrins in the regulation of cell migration and tissue assembly

被引：366
作者：
Poliakov, A [1 ]
Cotrina, M [1 ]
Wilkinson, DG [1 ]
机构：
[1] Natl Inst Med Res, Div Dev Neurobiol, London NW7 1AA, England
来源：
DEVELOPMENTAL CELL | 2004年 / 7卷 / 04期
关键词：
D O I：
10.1016/j.devcel.2004.09.006
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Eph receptor tyrosine kinases and ephrins have key roles in regulation of the migration and adhesion of cells required to form and stabilize patterns of cell organization during development. Activation of Eph receptors or ephrins can lead either to cell repulsion or to cell adhesion and invasion, and recent work has found that cells can switch between these distinct responses. This review will discuss biochemical mechanisms and developmental roles of the diverse cell responses controlled by Eph receptors and ephrins.
引用
收藏
页码：465 / 480
页数：16
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共 179 条
  • [91] The carboxyl terminus of B class ephrins constitutes a PDZ domain binding motif
    Lin, D
    Gish, GD
    Songyang, Z
    Pawson, T
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (06) : 3726 - 3733
  • [92] Coexpression of ephrin-Bs and their receptors in colon carcinoma
    Liu, WB
    Ahmad, SA
    Jung, YD
    Reinmuth, N
    Fan, F
    Bucana, CD
    Ellis, LM
    [J]. CANCER, 2002, 94 (04) : 934 - 939
  • [93] Ephrin-B reverse signaling is mediated by a novel PDZ-RGS protein and selectively inhibits G protein-coupled chemoattraction
    Lu, Q
    Sun, EE
    Klein, RS
    Flanagan, JG
    [J]. CELL, 2001, 105 (01) : 69 - 79
  • [94] Ephrin-B2 induces migration of endothelial cells through the phosphatidylinositol-3 kinase pathway and promotes angiogenesis in adult vasculature
    Maekawa, H
    Oike, Y
    Kanda, S
    Ito, Y
    Yamada, Y
    Kurihara, H
    Nagai, R
    Suda, T
    [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2003, 23 (11) : 2008 - 2014
  • [95] Role of Rho-family proteins in cell adhesion and cancer
    Malliri, A
    Collard, JG
    [J]. CURRENT OPINION IN CELL BIOLOGY, 2003, 15 (05) : 583 - 589
  • [96] B-type Eph receptors and ephrins induce growth cone collapse through distinct intracellular pathways
    Mann, F
    Miranda, E
    Weinl, C
    Harmer, E
    Holt, CE
    [J]. JOURNAL OF NEUROBIOLOGY, 2003, 57 (03): : 323 - 336
  • [97] Topographic mapping in dorsoventral axis of the xenopus retinotectal system depends on signaling through ephrin-13 ligands
    Mann, F
    Ray, S
    Harris, WA
    Holt, CE
    [J]. NEURON, 2002, 35 (03) : 461 - 473
  • [98] Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases
    Marmor, MD
    Yarden, Y
    [J]. ONCOGENE, 2004, 23 (11) : 2057 - 2070
  • [99] Rac-dependent trans-endocytosis of ephrinBs regulates Eph-ephrin contact repulsion
    Marston, DJ
    Dickinson, S
    Nobes, CD
    [J]. NATURE CELL BIOLOGY, 2003, 5 (10) : 879 - 888
  • [100] Bifunctional action of ephrin-B1 as a repellent and attractant to control bidirectional branch extension in dorsal-ventral retinotopic mapping
    McLaughlin, T
    Hindges, R
    Yates, PA
    O'Leary, DM
    [J]. DEVELOPMENT, 2003, 130 (11): : 2407 - 2418
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