Peripheral tryptophan, serotonin, kynurenine, and their metabolites in major depression: A case-control study

被引：58

作者：

Colle, Romain ^{[1
,2
]}

Masson, Perrine ^{[3
]}

Verstuyft, Celine ^{[1
,4
]}

Feve, Bruno ^{[5
,6
]}

Werner, Erwan ^{[3
]}

Boursier-Neyret, Claire ^{[3
]}

Walther, Bernard ^{[3
]}

David, Denis J. ^{[1
]}

Boniface, Bruno ^{[1
]}

Falissard, Bruno ^{[1
,7
]}

Chanson, Philippe ^{[8
,9
]}

Corruble, Emmanuelle ^{[1
,2
]}

Becquemont, Laurent ^{[1
,4
]}

机构：

[1] Paris Saclay Univ, Fac Med Paris Sud, CESP, INSERM UMR 1178, Le Kremlin Bicetre, France

[2] Hop Univ Paris Sud, Serv Hosp Univ Psychiat, Hop Bicetre, AP HP, Le Kremlin Bicetre, France

[3] Technol Servier, Pharmacokinet Ctr, Orleans, France

[4] Hop Univ Paris Sud, Hop Bicetre, AP HP, Serv Genet Mol Pharmacogenet & Hormonol, Le Kremlin Bicetre, France

[5] Hop St Antoine, AP HP, Serv Endocrinol, Paris, France

[6] Sorbonne Univ, INSERM UMR S 938, Ctr Rech St Antoine, Paris, France

[7] Paris Sud Univ, Hop Paul Brousse, AP HP, Dept Biostat, Villejuif, France

[8] Hop Bicetre, AP HP, Serv Endocrinol & Malad Reprod, Ctr Reference Malad Rares Hypophyse, F-94275 Le Kremlin Bicetre, France

[9] Paris Sud Univ, Paris Saclay Univ, Fac Med Paris Sud, INSERM 1185, Le Kremlin Bicetre, France

来源：

PSYCHIATRY AND CLINICAL NEUROSCIENCES | 2020年 / 74卷 / 02期

关键词：

3-hydroxyanthranilic acid; kynurenic acid; nicotinamide; picolinic acidxanthurenic acid; PLATELET SEROTONIN; CEREBROSPINAL-FLUID; PLASMA TRYPTOPHAN; DISORDER; PATHWAY; ASSOCIATION; ACID; CLOMIPRAMINE; BRAIN; BLOOD;

D O I：

10.1111/pcn.12944

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Aim Tryptophan is the sole precursor of both peripherally and centrally produced serotonin and kynurenine. In depressed patients, tryptophan, serotonin, kynurenine, and their metabolite levels remain unclear. Therefore, peripheral tryptophan and metabolites of serotonin and kynurenine were investigated extensively in 173 patients suffering from a current major depressive episode (MDE) and compared to 214 healthy controls (HC). Methods Fasting plasma levels of 11 peripheral metabolites were quantified: tryptophan, serotonin pathway (serotonin, its precursor 5-hydroxytryptophan and its metabolite 5-hydroxyindoleacetic acid), and kynurenine pathway (kynurenine and six of its metabolites: anthranilic acid, kynurenic acid, nicotinamide, picolinic acid, xanthurenic acid, and 3-hydroxyanthranilic acid). Results Sixty (34.7%) patients were antidepressant-drug free. Tryptophan levels did not differ between MDE patients and HC. Serotonin and its precursor (5-hydroxytryptophan) levels were lower in MDE patients than in HC, whereas, its metabolite (5-hydroxyindoleacetic acid) levels were within the standard range. Kynurenine and four of its metabolites (kynurenic acid, nicotinamide, picolinic acid, and xanthurenic acid) were lower in MDE patients. Conclusion Whilst the results of this study demonstrate an association between the metabolites studied and depression, conclusions about causality cannot be made. This study uses the largest ever sample of MDE patients, with an extensive assessment of peripheral tryptophan metabolism in plasma. These findings provide new insights into the peripheral signature of MDE. The reasons for these changes should be further investigated. These results might suggest new antidepressant therapeutic strategies.

引用

页码：112 / 117

页数：6

共 52 条

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