Intrinsically Disordered Proteins as Regulators of Transient Biological Processes and as Untapped Drug Targets

被引：21

作者：

Hosoya, Yusuke ^{[1
]}

Ohkanda, Junko ^{[1
]}

机构：

[1] Shinshu Univ, Acad Assembly, Inst Agr, 8304 Minami Minowa, Nagano 3994598, Japan

来源：

MOLECULES | 2021年 / 26卷 / 08期

基金：

日本学术振兴会;

关键词：

intrinsically disordered proteins; protein– protein interactions; liquid– liquid phase separation; drug discovery; PHASE-SEPARATION; POSTTRANSLATIONAL MODIFICATIONS; TRANSCRIPTION FACTOR; C-MYC; STRESS GRANULES; DNA-BINDING; DOMAIN; COMPLEX; CANCER; TDP-43;

D O I：

10.3390/molecules26082118

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Intrinsically disordered proteins (IDPs) are critical players in the dynamic control of diverse cellular processes, and provide potential new drug targets because their dysregulation is closely related to many diseases. This review focuses on several medicinal studies that have identified low-molecular-weight inhibitors of IDPs. In addition, clinically relevant liquid-liquid phase separations-which critically involve both intermolecular interactions between IDPs and their posttranslational modification-are analyzed to understand the potential of IDPs as new drug targets.

引用

页数：14

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