The correlation of microRNA-181a and target genes with poor prognosis of glioblastoma patients

被引：16

作者：

Huang, Shi-Xiong ^{[1
]}

Zhao, Zhong-Yan ^{[1
]}

Weng, Guo-Hu ^{[1
]}

He, Xiang-Ying ^{[1
]}

Wu, Chan-Ji ^{[1
]}

Fu, Chuan-Yi ^{[2
]}

Sui, Zhi-Yan ^{[1
]}

Zhong, Xiao-Ming ^{[3
]}

Liu, Tao ^{[1
]}

机构：

[1] Peoples Hosp Hainan Prov, Dept Neurol, Haikou 570311, Hainan, Peoples R China

[2] Peoples Hosp Hainan Prov, Dept Neurosurg, Haikou 570311, Hainan, Peoples R China

[3] Ganzhou City Peoples Hosp, Dept Radiol, Ganzhou 341000, Jiangxi, Peoples R China

来源：

INTERNATIONAL JOURNAL OF ONCOLOGY | 2016年 / 49卷 / 01期

关键词：

glioblastoma multiforme; miR-181a; target genes; GO analysis; overall survival; prognosis; GLIOMA-CELLS; PROLIFERATION; INVASION; ANGIOGENESIS; SUPPRESSION; PROGRESSION; EXPRESSION; BIOMARKERS; APOPTOSIS; THERAPY;

D O I：

10.3892/ijo.2016.3511

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To investigate the expression and clinical significance of miR-181a and its target genes in glioblastoma multiforme (GBM), the expression levels of miR-181a and three target genes in human normal brain tissues and GBM were analyzed in silico using gene microarray, Gene Ontology, KEGG pathway and hierarchical clustering analysis followed by validation with quantitative RT-PCR. Our results show that miR-181a is down-regulated in GBM patients. The three target genes, ANGPT2, ARHGAP18 and LAMC1, are negatively correlated with the expression of miR-181a. Moreover, high expression of ANGPT2 or LAMC1 together with large size of GBM is correlated with a shorter median overall survival. In conclusion, our results showed that miR-181a and it targets ANGPT2 and LAMC1 might be predictors of prognosis in GBM patients.

引用

页码：217 / 224

页数：8

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