Correlations between carotid IMT, factor VIII activity level and metabolic disturbances: A cardio-vascular risk factor in the HIV positive persons

被引：6

作者：

de Saint Martin, Luc ^{[1
]}

Pasquier, Elisabeth ^{[1
]}

Vandhuick, Olivier ^{[1
]}

Arnaud, Bertrand ^{[1
]}

Vallet, Sophie ^{[1
]}

Duchemin, Jerome ^{[1
]}

Bellein, Veronique ^{[1
]}

Bressollette, Luc ^{[1
]}

机构：

[1] Brest Univ Hosp, Brest, France

来源：

CURRENT HIV RESEARCH | 2007年 / 5卷 / 03期

关键词：

D O I：

10.2174/157016207780636498

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In the HIV infection, the short time-scale between the HIV-induced cardiovascular events and the onset of antiretroviral therapy elicits a thrombophilic co-factor that worsens the induced atherosclerosis. We compared the factor VIII plasma activity, previously implicated in arterial and venous thrombosis, with a Surrogate marker of atherosclerosis, the carotid intima-media thickness, and with the usual atherosclerosis risk factors in 154 HIV infected outpatients. The FVIII plasma activity is significantly associated with the carotid intima-media thickness and, strongly, with blood glucose and triglycerides levels. A raised FVIII plasma activity is an important feature of the metabolic syndrome and a putative co-factor of HAART induced cardiovascular events. Thus the prevention of the HAART-induced cardio-vascular events should probably not be exclusively focused oil atherosclerosis but likewise on the thrombus formation process.

引用

页码：361 / 364

页数：4