Intermittent ibandronate preserves bone quality and bone strength in the lumbar spine after 16 months of treatment in the ovariectomized cynomolgus monkey

被引：74
作者：
Müller, R
Hannan, M
Smith, SY
Bauss, F
机构：
[1] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Orthopaed Biomech Lab, Boston, MA 02115 USA
[2] CTBR Biores Inc, Div Pathol, Senneville, PQ, Canada
[3] Roche Diagnost GmbH, Penzberg, Germany
[4] Heidelberg Univ, Inst Pharmacol & Toxicol, D-6800 Mannheim, Germany
来源：
JOURNAL OF BONE AND MINERAL RESEARCH | 2004年 / 19卷 / 11期
关键词：
bone quality; bone strength; bisphosphonate treatment; mu CT; non-human primates;
D O I：
10.1359/JBMR.040809
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The dose-dependent effect of ibandronate treatment on bone mass and architecture was assessed in a large animal study of OVX monkeys using muCT for quantitative bone morphometry and biomechanical testing for measures of bone strength. The study showed that intermittent ibandronate preserved lumbar spine bone quality and strength in these animals after 16 months of treatment.
引用
收藏
页码：1787 / 1796
页数：10
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