Facile fabrication of monodisperse CoFe2O4 nanocrystals@dopamine@DOX hybrids for magnetic-responsive on-demand cancer theranostic applications

被引：22

作者：

Jia, Wenwen ^{[1
]}

Qi, Yiyao ^{[1
]}

Hu, Zhenrong ^{[2
]}

Xiong, Zuquan ^{[3
]}

Luo, Zhenyi ^{[1
]}

Xiang, Zhen ^{[1
]}

Hu, Jingzhou ^{[2
]}

Lu, Wei ^{[1
]}

机构：

[1] Tongji Univ, Shanghai East Hosp, Natl Stem Cell Translat Resource Ctr, Inst Regenerat Med,Sch Life Sci & Technol, Shanghai 200092, Peoples R China

[2] Shanghai Jiao Tong Univ, Dept Oral & Maxillofacial Head & Neck Oncol, Peoples Hosp 9, Sch Med, Shanghai 200011, Peoples R China

[3] Fudan Univ, Huashan Hosp, Dept Urol, Shanghai 200032, Peoples R China

来源：

ADVANCED COMPOSITES AND HYBRID MATERIALS | 2021年 / 4卷 / 04期

关键词：

CoFe2O4; Cancer theranostic nanoplatform; Magnetic hyperthermia; Controlled drug delivery; MICROWAVE ABSORBER; NANOPARTICLES; ABSORPTION; FE3O4; NANOCOMPOSITES; PERFORMANCE; CO;

D O I：

10.1007/s42114-021-00276-3

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Developing a multifunctional theranostic nanoplatform is vital for dealing with challenging matters correlated with cancers. In this paper, we report an improved facile and relatively green fabrication of highly monodisperse CoFe2O4 nanoparticles with tunable size and morphology. Furthermore, a multifunctional cancer theranostic nanoplatform (CoFe2O4 nanoparticles@dopamine@DOX) was successfully developed for magnetic-responsive on-demand hyperthermia and chemotherapy synergistic theranostics. The proposed nanoplatform exhibits outstanding magneto-triggered hyperthermia efficiency, magnetic-responsive controlled drug delivery capability, enhanced MRI T2-weighted signal, and good biocompatibility. More importantly, the in vivo tumor-bearing mouse model experiments indicated that the CoFe2O4 nanoparticles@dopamine@DOX nanomedicine could realize the functions of magnetic-responsive on-demand hyperthermia and DOX release, which significantly promoted the inactive condition of cancer cells and resulted in obvious tumor regression without evident toxic side effects. According to its facile and green fabrication approach, magneto-triggered high hyperthermia efficiency, magnetic-responsive on-demand cancer therapy, and noninvasive imaging mode, this multifunctional nanoplatform holds great advantages over traditional monotherapy techniques and provides an alternative for the precise clinical treatment of cancer.

引用

页码：989 / 1001

页数：13

共 29 条

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