Solubility of Δ9-tetrahydrocannabinol in supercritical carbon dioxide: Experiments and modeling

被引：55

作者：

Perrotin-Brunel, Helene ^{[1
]}

Perez, Pablo Cabeza ^{[1
]}

van Roosmalen, Maaike J. E. ^{[2
]}

van Spronsen, Jaap ^{[1
]}

Witkamp, Geert-Jan ^{[1
]}

Peters, Cor J. ^{[1
,3
]}

机构：

[1] Delft Univ Technol, Lab Proc Equipment, NL-2628 CA Delft, Netherlands

[2] FeyeCon D&I BV, NL-1382 GS Weesp, Netherlands

[3] Petr Inst, Abu Dhabi, U Arab Emirates

来源：

JOURNAL OF SUPERCRITICAL FLUIDS | 2010年 / 52卷 / 01期

关键词：

Solubility; Delta(9)-Tetrahydrocannabinol; Supercritical carbon dioxide; Anthracene; Peng-Robinson equation of state; FLUID EXTRACTION; ESSENTIAL OILS; FRACTIONATION; CANNABIS; SOLIDS;

D O I：

10.1016/j.supflu.2009.12.001

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The solubility of Delta(9)-tetrahydrocannabinol (Delta(9)-THC) in supercritical carbon dioxide has been determined at 315,327,334 and 345 K and in the pressure range from 13.2 to 25.1 MPa using an analytical method with a quasi-flow apparatus. Prior to performing these measurements, the method was validated by measuring anthracene solubilities and comparing these with literature values. The molar solubility for Delta(9)-THC ranged from 0.20 to 2.95 x 10(-4). The data were correlated using the Peng-Robinson equation of state in combination with quadratic mixing rules. Deviations between calculated results and the experimental data ranged from 4.1 to 13.3% absolute average relative deviation (AARD). (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：6 / 10

页数：5

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