Effect of the Mobile Phase Acid Additives on Enantioselectivity of Amino Acid Derivative Using Quinine Carbamate Based Chiral Stationary Phase

被引：0

作者：

Fegas, R. ^{[1
]}

Bensalem, A. ^{[1
]}

Bettache, Z. ^{[1
]}

Ouahba, F. ^{[1
]}

Righezza, M. ^{[1
]}

机构：

[1] Ecole Normale Super, Dept Chem, Vieux Kouba, Alger, Algeria

来源：

ASIAN JOURNAL OF CHEMISTRY | 2010年 / 22卷 / 02期

关键词：

Enantiomer separation; Chiral stationary phase; liquid chromatography; Mobile phase composition; Phthalylvalin; LIQUID-CHROMATOGRAPHIC ENANTIOSEPARATION; ANION-EXCHANGERS; ENANTIOMERS; SEPARATION;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Quinine carbamate-type chiral stationary phase has been used for the direct liquid chromatographic enantiomer separation of a wide range of chiral acids. In the present work, we demonstrate that this the chiral stationary phase can also be extended to chiral discrimination of amino acid derivative phthalylvalin using methanol containing different organic acids in mobile phases. The influence of mobile phase composition and enantioselectivity was systematically investigated to gain insight into the overall chiral recognition mechanism.

引用

页码：1582 / 1586

页数：5

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