The X-ray crystal structure of PA1607 from Pseudomonas aureginosa at 1.9 Å resolution -: a putative transcription factor

被引：5
作者：
Sieminska, Edyta A. L.
Xu, Xiaohui
Savchenko, Alexei
Sanders, David A. R.
机构：
[1] Univ Saskatchewan, Dept Chem, Saskatoon, SK S7N 5C9, Canada
[2] Univ Hlth Network, Ontario Ctr Struct Proteom, Toronto, ON M5G 2C4, Canada
来源：
PROTEIN SCIENCE | 2007年 / 16卷 / 03期
关键词：
transcription factor; winged-helix; crystal structure;
D O I：
10.1110/ps.062668207
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The structure of the PA1607 protein from Pseudomonas aureginosa was determined at 1.85 angstrom resolution using the Se-Met multiwavelength anomalous diffraction (MAD) technique. PA1607 forms a dimer and adopts a winged-helix motif similar to the MarR family of transcription regulators, though it has an unusual dimerization profile. The DNA-binding regions and a putative metal-binding site are not conserved in PA1607.
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收藏
页码：543 / 549
页数：7
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