Effects of hydrated forms of C60 fullerene on amyloid β-peptide fibrillization in vitro and performance of the cognitive task

被引：104
作者：
Podolski, I. Ya. [1 ]
Podlubnaya, Z. A.
Kosenko, E. A.
Mugantseva, E. A.
Makarova, E. G.
Marsagishvili, L. G.
Shpagina, M. D.
Kaminsky, Yu. G.
Andrievsky, G. V.
Klochkov, V. K.
机构：
[1] Russian Acad Sci, Inst Theoret & Expt Biophys, Pushchino 142292, Russia
[2] Pushchino State Univ, Pushchino 142292, Russia
[3] Ukraine Acad Med Sci, Inst Therapy, Kharkov, Ukraine
来源：
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | 2007年 / 7卷 / 4-5期
关键词：
hydrated C-60 fullerene; amyloid beta-peptide fibrillization; Alzheimer's disease; animal model; hippocampus; cognitive tasks;
D O I：
10.1166/jnn.2007.330
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
It has been shown for the first time by transmission electron microscopy that the hydrated fullerene C-60 inhibited the fibrillization of amyloid-beta(25-35) peptide. The fullerene affected the amyloid-beta(25-35) assembly, manifesting its anti-amyloidogenic capacity. Our in vivo investigations demonstrated also that a single intracerebroventricular injection of the C-60 hydrated fullerene at a dose of 7.2 nmol/ventricle significantly improved the performance of the cognitive task in control rats. The intracerebroventricular injection of the C-60 hydrated fullerene (3.6 nmol/ventricle) prevented the impairment of performance of the cognitive task induced by amyloid-beta(25-35) (22.5 nmol/ventricle). The results obtained may be useful in the development of therapy of Alzheimer's disease.
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收藏
页码：1479 / 1485
页数：7
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