Effects of hydrated forms of C60 fullerene on amyloid β-peptide fibrillization in vitro and performance of the cognitive task

被引：104

作者：

Podolski, I. Ya. ^{[1
]}

Podlubnaya, Z. A.

Kosenko, E. A.

Mugantseva, E. A.

Makarova, E. G.

Marsagishvili, L. G.

Shpagina, M. D.

Kaminsky, Yu. G.

Andrievsky, G. V.

Klochkov, V. K.

机构：

[1] Russian Acad Sci, Inst Theoret & Expt Biophys, Pushchino 142292, Russia

[2] Pushchino State Univ, Pushchino 142292, Russia

[3] Ukraine Acad Med Sci, Inst Therapy, Kharkov, Ukraine

来源：

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | 2007年 / 7卷 / 4-5期

关键词：

hydrated C-60 fullerene; amyloid beta-peptide fibrillization; Alzheimer's disease; animal model; hippocampus; cognitive tasks;

D O I：

10.1166/jnn.2007.330

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

It has been shown for the first time by transmission electron microscopy that the hydrated fullerene C-60 inhibited the fibrillization of amyloid-beta(25-35) peptide. The fullerene affected the amyloid-beta(25-35) assembly, manifesting its anti-amyloidogenic capacity. Our in vivo investigations demonstrated also that a single intracerebroventricular injection of the C-60 hydrated fullerene at a dose of 7.2 nmol/ventricle significantly improved the performance of the cognitive task in control rats. The intracerebroventricular injection of the C-60 hydrated fullerene (3.6 nmol/ventricle) prevented the impairment of performance of the cognitive task induced by amyloid-beta(25-35) (22.5 nmol/ventricle). The results obtained may be useful in the development of therapy of Alzheimer's disease.

引用

页码：1479 / 1485

页数：7

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