Activation rules: the two-signal theories of immune activation

被引：122

作者：

Baxter, AG

Hodgkin, PD

机构：

[1] Centenary Inst Canc Med & Cell Biol, Newtown, NSW 2042, Australia

[2] PO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

来源：

NATURE REVIEWS IMMUNOLOGY | 2002年 / 2卷 / 06期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/nri823

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Two-signal theories of lymphocyte activation have evolved considerably over the past 35 years. In this article, we examine the contemporary experimental observations and theoretical concerns that have helped to forge the most influential variants of the theory. We also propose that more-rigorous quantitative methods are required to sustain theoretical development in the future.

引用

页码：439 / 446

页数：8

共 53 条

[1]

BAXTER AG, 2000, GERM WARFARE BREAKTH

[2] ACTIVELY ACQUIRED TOLERANCE OF FOREIGN CELLS [J].