The MRN complex in double-strand break repair and telomere maintenance

被引：332

作者：

Lamarche, Brandon J. ^{[1
]}

Orazio, Nicole I. ^{[1
,2
]}

Weitzman, Matthew D. ^{[1
]}

机构：

[1] Salk Inst Biol Studies, Genet Lab, La Jolla, CA 92037 USA

[2] Univ Calif San Diego, Div Biol, Grad Program, San Diego, CA 92093 USA

来源：

FEBS LETTERS | 2010年 / 584卷 / 17期

基金：

美国国家卫生研究院;

关键词：

MRN complex; DNA damage; DNA repair; DSB; Telomere; DNA-DAMAGE RESPONSE; DEPENDENT PROTEIN-KINASE; TELANGIECTASIA-LIKE DISORDER; CLASS-SWITCH RECOMBINATION; MRE11; COMPLEX; CELL-CYCLE; HOMOLOGOUS RECOMBINATION; SACCHAROMYCES-CEREVISIAE; ATAXIA-TELANGIECTASIA; ATM ACTIVATION;

D O I：

10.1016/j.febslet.2010.07.029

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genomes are subject to constant threat by damaging agents that generate DNA double-strand breaks (DSBs). The ends of linear chromosomes need to be protected from DNA damage recognition and end-joining, and this is achieved through protein-DNA complexes known as telomeres. The Mre11-Rad50-Nbs1 (MRN) complex plays important roles in detection and signaling of DSBs, as well as the repair pathways of homologous recombination (HR) and non-homologous end-joining (NHEJ). In addition, MRN associates with telomeres and contributes to their maintenance. Here, we provide an overview of MRN functions at DSBs, and examine its roles in telomere maintenance and dysfunction. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：3682 / 3695

页数：14

共 177 条

[81] Differential requirements of the C terminus of Nbs1 in suppressing adenovirus DNA replication and promoting concatemer formation [J].

Lakdawala, Seema S. ;

Schwartz, Rachel A. ;

Ferenchak, Kevin ;

Carson, Christian T. ;

McSharry, Brian P. ;

Wilkinson, Gavin W. ;

Weitzman, Matthew D. .

JOURNAL OF VIROLOGY, 2008, 82 (17) :8362-8372

[82] The generation of proper constitutive G-tails on yeast telomeres is dependent on the MRX complex [J].

Larrivée, M ;

LeBel, C ;

Wellinger, RJ .

GENES & DEVELOPMENT, 2004, 18 (12) :1391-1396

[83] ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks [J].

Lavin, M. F. .

ONCOGENE, 2007, 26 (56) :7749-7758

[84] ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex [J].

Lee, JH ;

Paull, TT .

SCIENCE, 2005, 308 (5721) :551-554

[85] 53BP1 promotes ATM activity through direct interactions with the MRN complex [J].

Lee, Ji-Hoon ;

Goodarzi, Aaron A. ;

Jeggo, Penny A. ;

Paull, Tanya T. .

EMBO JOURNAL, 2010, 29 (03) :574-585

[86]

Lee Jong-Soo, 2007, Cancer Res Treat, V39, P125, DOI 10.4143/crt.2007.39.3.125

[87] Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex [J].

Lengsfeld, Bettina M. ;

Rattray, Alison J. ;

Bhaskara, Venugopal ;

Ghirlando, Rodolfo ;

Paull, Tanya T. .

MOLECULAR CELL, 2007, 28 (04) :638-651

[88] Using or abusing: viruses and the cellular DNA damage response [J].

Lilley, Caroline E. ;

Schwartz, Rachel A. ;

Weitzman, Matthew D. .

TRENDS IN MICROBIOLOGY, 2007, 15 (03) :119-126

[89] DNA repair proteins affect the lifecycle of herpes simplex virus 1 [J].

Lilley, CE ;

Carson, CT ;

Muotri, AR ;

Gage, FH ;

Weitzman, MD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (16) :5844-5849

[90] Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination [J].

Limbo, Oliver ;

Chahwan, Charly ;

Yamada, Yoshiki ;

de Bruin, Robertus A. M. ;

Wittenberg, Curt ;

Russell, Paul .

MOLECULAR CELL, 2007, 28 (01) :134-146

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