The MRN complex in double-strand break repair and telomere maintenance

被引：332

作者：

Lamarche, Brandon J. ^{[1
]}

Orazio, Nicole I. ^{[1
,2
]}

Weitzman, Matthew D. ^{[1
]}

机构：

[1] Salk Inst Biol Studies, Genet Lab, La Jolla, CA 92037 USA

[2] Univ Calif San Diego, Div Biol, Grad Program, San Diego, CA 92093 USA

来源：

FEBS LETTERS | 2010年 / 584卷 / 17期

基金：

美国国家卫生研究院;

关键词：

MRN complex; DNA damage; DNA repair; DSB; Telomere; DNA-DAMAGE RESPONSE; DEPENDENT PROTEIN-KINASE; TELANGIECTASIA-LIKE DISORDER; CLASS-SWITCH RECOMBINATION; MRE11; COMPLEX; CELL-CYCLE; HOMOLOGOUS RECOMBINATION; SACCHAROMYCES-CEREVISIAE; ATAXIA-TELANGIECTASIA; ATM ACTIVATION;

D O I：

10.1016/j.febslet.2010.07.029

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genomes are subject to constant threat by damaging agents that generate DNA double-strand breaks (DSBs). The ends of linear chromosomes need to be protected from DNA damage recognition and end-joining, and this is achieved through protein-DNA complexes known as telomeres. The Mre11-Rad50-Nbs1 (MRN) complex plays important roles in detection and signaling of DSBs, as well as the repair pathways of homologous recombination (HR) and non-homologous end-joining (NHEJ). In addition, MRN associates with telomeres and contributes to their maintenance. Here, we provide an overview of MRN functions at DSBs, and examine its roles in telomere maintenance and dysfunction. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：3682 / 3695

页数：14

共 177 条

[11] Double functions for the Mre11 complex during DNA double-strand break repair and replication [J].

Borde, Valerie ;

Cobb, Jennifer .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2009, 41 (06) :1249-1253

[12] Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing [J].

Boulton, SJ ;

Jackson, SP .

EMBO JOURNAL, 1998, 17 (06) :1819-1828

[13] Adenovirus E4 34k and E4 11k inhibit double strand break repair and are physically associated with the cellular DNA-dependent protein kinase [J].

Boyer, J ;

Rohleder, K ;

Ketner, G .

VIROLOGY, 1999, 263 (02) :307-312

[14] Regulation of DNA repair throughout the cell cycle [J].

Branzei, Dana ;

Foiani, Marco .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2008, 9 (04) :297-308

[15] Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation [J].

Buis, Jeffrey ;

Wu, Yipin ;

Deng, Yibin ;

Leddon, Jennifer ;

Westfield, Gerwin ;

Eckersdorff, Mark ;

Sekiguchi, JoAnn M. ;

Chang, Sandy ;

Ferguson, David O. .

CELL, 2008, 135 (01) :85-96

[16] Dimerization of the Rad50 protein is independent of the conserved hook domain [J].

Cahill, Dana ;

Carney, James P. .

MUTAGENESIS, 2007, 22 (04) :269-274

[17] The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: Linkage of double-strand break repair to the cellular DNA damage response [J].

Carney, JP ;

Maser, RS ;

Olivares, H ;

Davis, EM ;

Le Beau, M ;

Yates, JR ;

Hays, L ;

Morgan, WF ;

Petrini, JHJ .

CELL, 1998, 93 (03) :477-486

[18] Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection [J].

Carson, Christian T. ;

Orazio, Nicole I. ;

Lee, Darwin V. ;

Suh, Junghae ;

Bekker-Jensen, Simon ;

Araujo, Felipe D. ;

Lakdawala, Seema S. ;

Lilley, Caroline E. ;

Bartek, Jiri ;

Lukas, Jiri ;

Weitzman, Matthew D. .

EMBO JOURNAL, 2009, 28 (06) :652-662

[19] The Mre11 complex is required for ATM activation and the G2/M checkpoint [J].

Carson, CT ;

Schwartz, RA ;

Stracker, TH ;

Lilley, CE ;

Lee, DV ;

Weitzman, MD .

EMBO JOURNAL, 2003, 22 (24) :6610-6620

[20] DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion [J].

Celli, GB ;

de Lange, T .

NATURE CELL BIOLOGY, 2005, 7 (07) :712-U110

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