Fungicidal and anti-aflatoxin activity of four meroterpenoids isolated from Arnebia euchroma root

被引：4

作者：

Madarshahi, Fatemeh Sadat ^{[1
]}

Taghizadeh, Seyedeh Faezeh ^{[2
,3
]}

Rezaee, Ramin ^{[4
,5
]}

Azizi, Majid ^{[2
]}

Asili, Javad ^{[6
]}

Karimi, Gholamreza ^{[3
,7
]}

机构：

[1] Islamic Azad Univ, Fac Agr, Dept Hort Sci, Shirvan Branch, Shirvan, Iran

[2] Ferdowsi Univ Mashhad, Fac Agr, Dept Hort Sci, POB 1365-91775, Mashhad, Razavi Khorasan, Iran

[3] Mashhad Univ Med Sci, Pharmaceut Res Ctr, Pharmaceut Technol Inst, Mashhad, Razavi Khorasan, Iran

[4] Mashhad Univ Med Sci, Fac Med, Int UNESCO Ctr Hlth Related Basic Sci & Human Nut, Mashhad, Razavi Khorasan, Iran

[5] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Razavi Khorasan, Iran

[6] Mashhad Univ Med Sci, Fac Pharm, Dept Pharmacognosy, Mashhad, Razavi Khorasan, Iran

[7] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Razavi Khorasan, Iran

来源：

TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY | 2022年 / 104卷 / 02期

关键词：

Bio-control; bio-fungicide; fungicidal activity; eco-friendly; hazard contaminates; mycotoxin; FORMYL-PHLOROGLUCINOL MEROTERPENOIDS; ROSMARINUS-OFFICINALIS L; ESSENTIAL OIL; ANTIFUNGAL ACTIVITY; ASPERGILLUS-FLAVUS; CLAVILACTONES; INHIBITION; LEAVES;

D O I：

10.1080/02772248.2022.2104279

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Meroterpenoids are naturally occurring bioactive compounds derived from terpenoids. Isolation and structure elucidation of four meroterpenoids from Arnebia euchroma root confirmed as arnebinol A-D have been conducted and their antifungal and anti-aflatoxigenic activities against Aspergillus flavus have been investigated. Scanning electron microscopy revealed that after treating A. flavus with arnebinol A-D at >= 200 mg/L, the conidia with phialides appeared wrinkled and compressed, the cell wall was damaged, and mycelia! growth was entirely inhibited. Arnebinol D could inhibit A. flavus aflatoxin production and reduce ergosterol levels. The present experiments confirmed the antifungal activity of arnebinol D and provided evidence for the potential use of these natural compounds against fungi.

引用

页码：263 / 279

页数：17

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