RETRACTED: Long non-coding RNA TTN-AS1 promotes the metastasis in breast cancer by epigenetically activating DGCR8 (Retracted Article)

被引：10
|
作者：
Qiu, P. [1 ]
Dou, Y. [2 ]
Ma, L-Z [2 ]
Tang, X-X [1 ]
Liu, X-L [2 ]
Chen, J-W [2 ]
机构：
[1] Xingtai Peoples Hosp, Dept Med Oncol, Xingtai, Peoples R China
[2] Xingtai Peoples Hosp, Dept Pathol, Xingtai, Peoples R China
来源：
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES | 2019年 / 23卷 / 24期
关键词：
Long non-coding RNA; TTN-AS1; BC; DGCR8; PROLIFERATION; PROGRESSION; STATISTICS;
D O I：
10.26355/eurrev_201912_19787
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
OBJECTIVE: Breast cancer (BC) is one of the most common fatal cancers. Recent studies have identified the vital roles of long non-coding RNAs (lncRNAs) in the development and progression of BC. This research aimed to investigate the underlying mechanisms of lncRNA TTN-AS1 in the metastasis of BC. PATIENTS AND METHODS: TTN-AS1 expression of tissues was detected by Real Time-quantitative Polymerase Chain Reaction (RT-qPCR) in 50 BC patients. Wound healing assay and transwell assay were used to observe the phenotypic alteration of BC cells after knockdown or overexpression of TTN-AS1. Moreover. RT-qPCR and Western blot assay were performed to discover the potential targets of TTN-AS1 in BC. RESULTS: TTN-AS1 expression in BC samples was significantly higher than that of the adjacent tissues. Besides, the migration and invasion of BC cells were markedly inhibited after TTN-AS1 was silenced, while promoted after TTN-AS1 overexpression. In addition, a remarkable decrease of DGCR8 was observed after TTN-AS1 was inhibited in BC cells. while DGCR8 was upregulated after overexpression of TTN-AS1. Furthermore, DGCR8 expression showed significant enhancement in BC tissues and was positively associated with TTN-AS1 level. CONCLUSIONS: Our study uncovered a new oncogene in BC and suggested that TTN-AS1 could enhance BC cell migration and invasion via sponging DGCR8, which provided a novel therapeutic target for the treatment of breast cancer.
引用
收藏
页码：10835 / 10841
页数：7
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