Role of Cripto-1 in Stem Cell Maintenance and Malignant Progression

被引:107
作者
Bianco, Caterina [1 ]
Rangel, Maria Cristina [1 ]
Castro, Nadia P. [1 ]
Nagaoka, Tadahiro [1 ]
Rollman, Kelly [1 ]
Gonzales, Monica [1 ]
Salomon, David S. [1 ]
机构
[1] NCI, Mammary Biol & Tumorigenesis Lab, NIH, Ctr Canc Res, Bethesda, MD 20892 USA
基金
美国国家卫生研究院;
关键词
EPITHELIAL-MESENCHYMAL TRANSITION; HYPOXIA-INDUCIBLE FACTORS; LEFT-RIGHT ASYMMETRY; NODAL EXPRESSION; GENE-EXPRESSION; MAMMARY-GLAND; EMBRYONIC-DEVELOPMENT; REGULATORY CIRCUITRY; TRANSGENIC MICE; SELF-RENEWAL;
D O I
10.2353/ajpath.2010.100102
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Cripto-1 is critical for early embryonic development and, together with its ligand Nodal, has been found to be associated with the undifferentiated status of mouse and human embryonic stem cells. Like other embryonic genes, Cripto-1 performs important roles in the formation and progression of several types of human tumors, stimulating cell proliferation, migration, epithelial to mesenchymal transition, and tumor angiogenesis. Several studies have demonstrated that cell fate regulation during embryonic development and cell transformation during oncogenesis share common signaling pathways, suggesting that uncontrolled activation of embryonic signaling pathways might drive cell transformation and tumor progression in adult tissues. Here we review our current understanding of how Cripto-1 controls stem cell biology and how it integrates with other major embryonic signaling pathways. Because many cancers are thought to derive from a subpopulation of cancer stem-like cells, which may re-express embryonic genes, Cripto-1 signaling may drive tumor growth through the generation or expansion of tumor initiating cells bearing stem-like characteristics. Therefore, the Cripto-1/Nodal signaling may represent an attractive target for treatment in cancer, leading to the elimination of undifferentiated stem-like tumor initiating cells. (Am J Pathol 2010, 177:532-540; DOI: 10.2353/ajpath.2010.100102)
引用
收藏
页码:532 / 540
页数:9
相关论文
共 69 条
[1]   Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes [J].
Aasen, Trond ;
Raya, Angel ;
Barrero, Maria J. ;
Garreta, Elena ;
Consiglio, Antonella ;
Gonzalez, Federico ;
Vassena, Rita ;
Bilic, Josipa ;
Pekarik, Vladimir ;
Tiscornia, Gustavo ;
Edel, Michael ;
Boue, Stephanie ;
Izpisua Belmonte, Juan Carlos .
NATURE BIOTECHNOLOGY, 2008, 26 (11) :1276-1284
[2]   Characterization of human embryonic stem cell lines by the International Stem Cell Initiative [J].
Adewumi, Oluseun ;
Aflatoonian, Behrouz ;
Ahrlund-Richter, Lars ;
Amit, Michal ;
Andrews, Peter W. ;
Beighton, Gemma ;
Bello, Paul A. ;
Benvenisty, Nissim ;
Berry, Lorraine S. ;
Bevan, Simon ;
Blum, Barak ;
Brooking, Justin ;
Chen, Kevin G. ;
Choo, Andre B. H. ;
Churchill, Gary A. ;
Corbel, Marie ;
Damjanov, Ivan ;
Draper, Jon S. ;
Dvorak, Petr ;
Emanuelsson, Katarina ;
Fleck, Roland A. ;
Ford, Angela ;
Gertow, Karin ;
Gertsenstein, Marina ;
Gokhale, Paul J. ;
Hamilton, Rebecca S. ;
Hampl, Ales ;
Healy, Lyn E. ;
Hovatta, Outi ;
Hyllner, Johan ;
Imreh, Marta P. ;
Itskovitz-Eldor, Joseph ;
Jackson, Jamie ;
Johnson, Jacqueline L. ;
Jones, Mark ;
Kee, Kehkooi ;
King, Benjamin L. ;
Knowles, Barbara B. ;
Lako, Majlinda ;
Lebrin, Franck ;
Mallon, Barbara S. ;
Manning, Daisy ;
Mayshar, Yoav ;
Mckay, Ronald D. G. ;
Michalska, Anna E. ;
Mikkola, Milla ;
Mileikovsky, Masha ;
Minger, Stephen L. ;
Moore, Harry D. ;
Mummery, Christine L. .
NATURE BIOTECHNOLOGY, 2007, 25 (07) :803-816
[3]   Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development [J].
Andersson, Olov ;
Bertolino, Philippe ;
Ibanez, Carlos F. .
DEVELOPMENTAL BIOLOGY, 2007, 311 (02) :500-511
[4]   Synergistic interaction between Gdf1 and Nodal during anterior axis development [J].
Andersson, Olov ;
Reissmann, Eva ;
Jornvall, Henrik ;
Ibanez, Carlos F. .
DEVELOPMENTAL BIOLOGY, 2006, 293 (02) :370-381
[5]   Generation of pluripotent stem cells from adult mouse liver and stomach cells [J].
Aoi, Takashi ;
Yae, Kojiro ;
Nakagawa, Masato ;
Ichisaka, Tomoko ;
Okita, Keisuke ;
Takahashi, Kazutoshi ;
Chiba, Tsutomu ;
Yamanaka, Shinya .
SCIENCE, 2008, 321 (5889) :699-702
[6]   Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells [J].
Babaie, Yasmin ;
Herwig, Ralf ;
Greber, Boris ;
Brink, Thore C. ;
Wruck, Wasco ;
Groth, Detlef ;
Lehrach, Hans ;
Burdon, Tom ;
Adjaye, James .
STEM CELLS, 2007, 25 (02) :500-510
[7]   Human embryonic stem cells:: lessons from stem cell niches in vivo [J].
Bendall, Sean C. ;
Stewart, Morag H. ;
Bhatia, Mickie .
REGENERATIVE MEDICINE, 2008, 3 (03) :365-376
[8]   An Enhanced Mass Spectrometry Approach Reveals Human Embryonic Stem Cell Growth Factors in Culture [J].
Bendall, Sean C. ;
Hughes, Chris ;
Campbell, J. Larry ;
Stewart, Morag H. ;
Pittock, Paula ;
Liu, Suya ;
Bonneil, Eric ;
Thibault, Pierre ;
Bhatia, Mickie ;
Lajoie, Gilles A. .
MOLECULAR & CELLULAR PROTEOMICS, 2009, 8 (03) :421-432
[9]   Cripto-1: An oncofetal gene with many faces [J].
Bianco, C ;
Strizzi, L ;
Normanno, N ;
Khan, N ;
Salomon, DS .
CURRENT TOPICS IN DEVELOPMENTAL BIOLOGY, VOL 67, 2005, 67 :85-133
[10]   Cripto-1 Is Required for Hypoxia to Induce Cardiac Differentiation of Mouse Embryonic Stem Cells [J].
Bianco, Caterina ;
Cotten, Catherine ;
Lonardo, Enza ;
Strizzi, Luigi ;
Baraty, Christina ;
Mancino, Mario ;
Gonzales, Monica ;
Watanabe, Kazuhide ;
Nagaoka, Tadahiro ;
Berry, Colin ;
Arai, Andrew E. ;
Minchiotti, Gabriella ;
Salomon, David S. .
AMERICAN JOURNAL OF PATHOLOGY, 2009, 175 (05) :2146-2158