Biodegradable Highly Branched Poly(β-Amino Ester)s for Targeted Cancer Cell Gene Transfection

被引：54

作者：

Liu, Shuai ^{[1
,2
]}

Gao, Yongsheng ^{[1
]}

Sigen, A. ^{[1
]}

Zhou, Dezhong ^{[1
]}

Greiser, Udo ^{[1
]}

Guo, Tianying ^{[2
]}

Guo, Rui ^{[3
]}

Wang, Wenxin ^{[1
]}

机构：

[1] Univ Coll Dublin, Charles Inst Dermatol, Sch Med, Dublin 4, Ireland

[2] Nankai Univ, Inst Polymer Chem, Coll Chem, Key Lab Funct Polymer Mat,Minist Educ, Tianjin 300071, Peoples R China

[3] Jinan Univ, Dept Biomed Engn, Guangzhou 510632, Guangdong, Peoples R China

来源：

ACS BIOMATERIALS SCIENCE & ENGINEERING | 2017年 / 3卷 / 07期

基金：

国家教育部博士点专项基金资助; 爱尔兰科学基金会; 中国国家自然科学基金;

关键词：

cancer cells; gene transfection; biodegradable; highly branched poly(beta-amino ester)s; targeting; DELIVERY; DNA;

D O I：

10.1021/acsbiomaterials.6b00503

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

To enhance the gene transfection efficiency to targeted cells while reducing the side effects to untargeted cells is of great significance for clinical gene therapy. Here, biodegradable highly branched poly(beta-amino ester)s (HPAESS) are synthesized and functionalized with folate (HPAESSFA) and lactobionic acid (HPAESS-Lac) for targeted cancer cell gene transfection. Results show that because of the triggered degradability of the vector and enhanced receptor mediated cellular uptake of polyplexes, the HPAESS-FA and HPAESS-Lac exhibit superior gene transfection capability in specific cancer cells with negligible cytotoxicity, pointing to their promise as targeted vectors for efficient cancer gene therapy.

引用

页码：1283 / 1286

页数：4

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