Resolving dyskinesias at sustained anti-OCD efficacy by steering of DBS away from the anteromedial STN to the mesencephalic ventral tegmentum - case report

被引：7

作者：

Coenen, Volker A. ^{[1
,2
,3
]}

Schlaepfer, Thomas E. ^{[2
,3
,4
]}

Meyer, Dora ^{[2
,4
]}

Kilian, Hannah ^{[2
,4
]}

Spanier, Susanne ^{[2
,4
]}

Sajonz, Bastian E. A. ^{[1
,2
]}

Reinacher, Peter C. ^{[1
,2
,5
]}

Reisert, Marco ^{[1
,2
,6
]}

机构：

[1] Freiburg Univ, Dept Stereotact & Funct Neurosurg, Med Ctr, Freiburg, Germany

[2] Freiburg Univ, Med Fac, Freiburg, Germany

[3] Freiburg Univ, Ctr Deep Brain Stimulat, Med Ctr, Freiburg, Germany

[4] Univ Hosp Freiburg, Dept Intervent Biol Psychiat, Freiburg, Germany

[5] Fraunhofer Inst Laser Technol ILT, Aachen, Germany

[6] Univ Freiburg, Dept Diagnost & Intervent Radiol, Med Phys, Med Ctr, Freiburg, Germany

来源：

ACTA NEUROCHIRURGICA | 2022年 / 164卷 / 09期

关键词：

Anteromedial STN; Case report; DBS; Directional; Focal; Mesencephalic ventral tegmentum; Obsessive-compulsive disorder; slMFB; ELECTRICAL-STIMULATION; NUCLEUS;

D O I：

10.1007/s00701-022-05206-w

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Here we describe therapeutic results in a female patient who underwent bilateral slMFB DBS for OCD. During a 35-month long course of stimulation, she suffered from stimulation-induced dyskinesia of her right leg which we interpreted as co-stimulation of the adjacent anteromedial subthalamic nucleus (amSTN). After reprogramming to steer the stimulation away from the amSTN medial into the direction of the mesencephalic ventral tegmentum (MVT which contains the ventral tegmental area, VTA), the dyskinesias disappeared. Remarkably, anti-OCD efficacy in the presented patient was preserved and achieved with a bilateral stimulation which by our imaging study fully avoided the amSTN.

引用

页码：2303 / 2307

页数：5

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