A chiral trick to map protein ligandability

被引：14

作者：

Amako, Yuka ^{[1
]}

Woo, Christina M. ^{[1
]}

机构：

[1] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA

来源：

NATURE CHEMISTRY | 2019年 / 11卷 / 12期

关键词：

D O I：

10.1038/s41557-019-0380-0

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Biological receptors distinguish between S- and R-enantiomers and these subtle differences in chirality can lead to vastly different protein affinities. Now, a proteomics approach has been developed that capitalizes on chirality to map enantiomeric probe pairs and provides a rapid and global view of protein ligandability within the cell.

引用

页码：1080 / 1082

页数：4

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