Ca2+-binding protein S100A11: A novel diagnostic marker for breast carcinoma

被引：28
|
作者：
Liu, Xiang-Guo [2 ]
Wang, Xiao-Ping [2 ]
Li, Wan-Feng [1 ]
Yang, Shuo [2 ]
Zhou, Xin [2 ]
Li, Si-Jie [1 ]
Li, Xiang-Jun [4 ]
Hao, Dong-Yun [2 ,3 ]
Fan, Zhi-Min [1 ]
机构：
[1] Jilin Univ, Hosp 1, Dept Breast Surg, Changchun 130021, Peoples R China
[2] Jilin Univ, Key Lab Mol Enzymol & Engn, Minist Educ, Changchun 130023, Peoples R China
[3] JAAS, Biotechnol Res Ctr, Changchun 130033, Peoples R China
[4] Jilin Univ, Sch Pharm, Dept Expt Pharmacol & Toxicol, Changchun 130021, Peoples R China
来源：
ONCOLOGY REPORTS | 2010年 / 23卷 / 05期
关键词：
S100A11; breast carcinoma; tumor marker; differential proteomics; HUMAN KERATINOCYTES; GENE-EXPRESSION; GROWTH-INHIBITION; HUMAN TISSUES; TUMOR-CELLS; CANCER; QUANTIFICATION; CARCINOGENESIS; IDENTIFICATION; CALGIZZARIN;
D O I：
10.3892/or_00000764
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
To evaluate whether S100A11 could be considered to be a novel diagnostic marker in breast carcinoma, the method of differential proteomics. Western blotting, and immunohistochemistry were used to detect the expression pattern and subcellular localization of S100A11. Statistical analyses indicated that specific up-regulated of A100A11 did not correlate with other prognostic factors such as age, tumor size, grade and stage, ER, PR, HER-2 and nodal status. Our data support that S100A11 is a novel diagnostic marker in breast carcinoma. Analysis of S100A11 expression in breast cancer may be an effective tool help in detection of early-stage breast cancer.
引用
收藏
页码：1301 / 1308
页数：8
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