Presynaptic Effect of Ethosuximide: a Study on a Cell-Free Model System

被引：0
|
作者：
Gromov, L. [2 ]
Syrovatska, L. [2 ]
Gumenyuk, V. [1 ]
Trikash, I. [1 ]
机构：
[1] Natl Acad Sci Ukraine, Palladin Inst Biochem, Kiev, Ukraine
[2] Ukraine Acad Med Sci, Inst Pharmacol & Toxicol, Kiev, Ukraine
来源：
NEUROPHYSIOLOGY | 2002年 / 34卷 / 2-3期
关键词：
cell-free model system; membrane fusion; ethosuximide; presynaptic activity;
D O I：
10.1023/A:1020762107801
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effect of an antiepileptic drug, ethosuximide, on fusion of synaptic vesicles with the synaptosomal plasma membranes was studied. It was shown that ethosuximide increases the rate of the Ca2+-dependent fusion reaction. We found that ethosuximide-induced fusion of synaptic vesicles with the plasma membrane in a Ca2+-free medium is much lower than the Ca2+-induced effect under the same conditions. Thus, the fusion-inducing effect of ethosuximide is mostly Ca2+-dependent. Ethosuximide-evoked fusion was suppressed by pentylenetetrazole.
引用
收藏
页码：141 / 143
页数：3
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