Autophagy: a decisive process for stemness

被引：20
作者：
Garcia-Prat, Laura [1 ]
Martinez-Vicente, Marta [2 ]
Munoz-Canoves, Pura [1 ,3 ]
机构：
[1] Pompeu Fabra Univ UPF, CIBER Neurodegenerat Dis CIBERNED, Dept Expt & Hlth Sci, Cell Biol Grp, Barcelona, Spain
[2] Vall dHebron Res Inst CIBERNED, Neurodegenerat Dis Res Grp, Barcelona, Spain
[3] ICREA, Barcelona, Spain
来源：
ONCOTARGET | 2016年 / 7卷 / 11期
基金：
欧盟第七框架计划;
关键词：
autophagy; stem cells; aging; muscle; senescence;
D O I：
10.18632/oncotarget.7766
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Mature skeletal muscle is a stable tissue imposing low homeostatic demand on its stem cells, which remain in a quiescent state in their niche over time. We have shown that these long-lived resting stem cells attenuate proteotoxicity and avoid senescence through basal autophagy. This protective "clean-up" system is lost during aging, resulting in stem cell regenerative decline. Thus, autophagy is required for muscle stem cell homeostasis maintenance.
引用
收藏
页码：12286 / 12288
页数：3
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