Neolignans from Piper kadsura and their anti-neuroinflammatory activity

被引：38

作者：

Kim, Ki Hyun ^{[1
]}

Choi, Jung Wook ^{[1
]}

Ha, Sang Keun ^{[2
]}

Kim, Sun Yeou ^{[2
]}

Lee, Kang Ro ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Coll Pharm, Nat Prod Lab, Suwon 440746, South Korea

[2] Kyung Hee Univ, EW Med Sci Integrated Res Ctr, Grad Sch EW Med Sci, Yongin 446701, Kyungki Do, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 01期

关键词：

Piper kadsura; Piperaceae; Neolignan; Anti-neuroinflammatory activity; NO production; INHIBITION; MICROGLIA; BRAIN;

D O I：

10.1016/j.bmcl.2009.10.016

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Bioassay-guided column chromatographic separation of the methanolic extract of dried aerial parts of Piper kadsura (Piperaceae) led to the isolation of a new neolignan, piperkadsin C (1), together with eight known neolignans (2-9). The structures of the isolated compounds were elucidated by combined spectroscopic methods. The anti-neuroinflammatory activities of these compounds were evaluated by assessing nitric oxide (NO) production in LPS-activated BV-2 cells, a microglia cell line. Piperkadsin C (1) and futoquinol (2) potently inhibited NO production with an IC50 value of 14.6 and 16.8 mu M in microglia cells, respectively. Compounds 3, 4, 5, 8, and 9 also exhibited moderate inhibition of NO production in BV-2 cells. (C) 2009 Published by Elsevier Ltd.

引用

页码：409 / 412

页数：4

共 26 条

[1] NEOLIGNANS FROM PIPER-FUTOKADSURA [J].