Factors Contributing to Outbreaks of Wild Poliovirus Type 1 Infection Involving Persons Aged ≥15 Years in the Democratic Republic of the Congo, 2010-2011, Informed by a Pre-Outbreak Poliovirus Immunity Assessment

被引:12
作者
Alleman, Mary M. [1 ]
Wannemuehler, Kathleen A. [1 ]
Weldon, William C. [2 ]
Kabuayi, Jean Pierre [3 ]
Ekofo, Felly [3 ]
Edidi, Samuel [3 ]
Mulumba, Audry [4 ]
Mbule, Albert [5 ]
Ntumbannji, Renee N. [5 ]
Coulibaly, Tiekoura [5 ]
Abiola, Nadine [6 ]
Mpingulu, Minlangu [6 ]
Sidibe, Kassim [6 ]
Oberste, M. Steven [2 ]
机构
[1] Ctr Dis Control & Prevent, Global Immunizat Div, Atlanta, GA 30333 USA
[2] Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA 30333 USA
[3] Minist Publ Hlth, Programme Natl Lutte IST SIDA, Kinshasa, DEM REP CONGO
[4] Minist Publ Hlth, Expanded Programme Immunizat, Kinshasa, DEM REP CONGO
[5] WHO, Immunizat Vaccines & Emergencies Cluster, Kinshasa, DEM REP CONGO
[6] Ctr Dis Control & Prevent, Div Global HIV AIDS, Kinshasa, DEM REP CONGO
关键词
polio eradication; polio seroprevalence; neutralizing antibodies; Democratic Republic of the Congo; Africa; wild poliovirus outbreaks; polio in adults; POLIOMYELITIS OUTBREAK; PARALYTIC POLIOMYELITIS;
D O I
10.1093/infdis/jiu282
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background. The Democratic Republic of the Congo (DRC) experienced atypical outbreaks of wild poliovirus type 1 (WPV1) infection during 2010-2011 in that they affected persons aged >= 15 years in 4 (Bandundu, Bas Congo, Kasai Occidental, and Kinshasa provinces) of the 6 provinces with outbreaks. Methods.aEuro integral Analyses of cases of WPV1 infection with onset during 2010-2011 by province, age, polio vaccination status, and sex were conducted. The prevalence of antibodies to poliovirus (PV) types 1, 2, and 3 was assessed in sera collected before the outbreaks from women attending antenatal clinics in 3 of the 4 above-mentioned provinces. Results.aEuro integral Of 193 cases of WPV1 infection during 2010-2011, 32 (17%) occurred in individuals aged a parts per thousand yen15 years. Of these 32 cases, 31 (97%) occurred in individuals aged 16-29 years; 9 (28%) were notified in Bandundu, 17 (53%) were notified in Kinshasa, and 22 (69%) had an unknown polio vaccination status. In the seroprevalence assessment, PV type 1 and 3 seroprevalence was lower among women aged 15-29 years in Bandundu and Kinshasa, compared with those in Kasa < Occidental. Seropositivity to PVs was associated with increasing age, more pregnancies, and a younger age at first pregnancy. Conclusions.aEuro integral This spatiotemporal analysis strongly suggests that the 2010-2011 outbreaks of WPV1 infection affecting young adults were caused by a PV type 1 immunity gap in Kinshasa and Bandundu due to insufficient exposure to PV type 1 through natural infection or vaccination. Poliovirus immunity gaps in this age group likely persist in DRC.
引用
收藏
页码:S62 / S73
页数:12
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