Opinion - Will telomere erosion lead to a loss of T-cell memory?

被引：100
作者：
Akbar, AN
Beverley, PCL
Salmon, M
机构：
[1] UCL Royal Free & Univ Coll Med Sch, Dept Immunol & Mol Pathol, Div Infect & Immun, London W1T 4JF, England
[2] Edward Jenner Inst Vaccine Res, Compton RG20 7NN, Berks, England
[3] Univ Birmingham, MRC, Ctr Immune Regulat, Birmingham B15 4TT, W Midlands, England
来源：
NATURE REVIEWS IMMUNOLOGY | 2004年 / 4卷 / 09期
基金：
英国生物技术与生命科学研究理事会;
关键词：
D O I：
10.1038/nri1440
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Evidence is accumulating that elderly individuals are more susceptible to infection with organisms to which they were previously immune. This indicates that there might be a limit to the persistence of immune memory. This fact is particularly disturbing because the average life expectancy of humans has almost doubled in the past 200 years and is still increasing. We discuss mechanisms that might constrain the persistence of memory T cells and consider whether humans will suffer from memory T-cell exhaustion as life expectancy increases.
引用
收藏
页码：737 / 743
页数：7
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