Prevalence and correlates of orthostatic hypotension in middle-aged men and women in Korea: the Korean Health and Genome Study

被引:106
作者
Shin, C
Abbott, RD
Lee, H
Kim, J
Kimm, K
机构
[1] Korean Natl Inst Hlth, Korean Natl Genome Inst, Seoul 122701, South Korea
[2] Korea Univ, Sch Med, Ansan Hosp, Inst Human Genom Study, Gyeonggi Do, South Korea
[3] Univ Virginia, Sch Med, Div Biostat & Epidemiol, Charlottesville, VA 22908 USA
关键词
orthostatic hypotension; epidemiology; blood pressure; Korea;
D O I
10.1038/sj.jhh.1001732
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
To examine the prevalence and correlates of orthostatic hypotension (OH) in middle-aged adults enrolled in the Korean Health and Genome Study. Participants were 8908 individuals aged 40-69 years. Supine blood pressure (BP) was measured three times at 30-s intervals after at least 5 min of rest in the supine position and single standing BP was measured at 0 and 2 min after standing, respectively. OH was defined as a reduction in systolic BP or diastolic BPgreater than or equal to20 and 10mmHg, respectively. The prevalence of OH at 0 and 2 min after standing was 12.3 and 2.9%, respectively. At 0 min of standing, OH frequency increased significantly with age from 6.4% in those aged 40-44 years to 23.1% in those aged 65-69 (P<0.001). After adjustment for age and other characteristics, hypertension was associated with a 1.7-fold excess in the odds of OH in men and a 1.6-fold excess in women (P<0.001). In contrast, an increase in body mass index (BMI) on the order of 5 kg/m(2) was associated with a 20-30% reduction in the odds of OH (P<0.001). Diabetes in women was also associated with a 1.4-fold excess in the odds of OH (P<0.05). An increase in triglyceride by 136 mg/dl in men was associated with an increase in the odds of OH (P<0.05). In conclusion, the prevalence and correlates of OH other than diabetes and triglycerides were notably similar in men and women. While the association between hypertension and OH has been observed elsewhere, low BMI in Korean adults with OH may be an important marker for subclinical morbidity or coexisting risk factors that need to be identified.
引用
收藏
页码:717 / 723
页数:7
相关论文
共 27 条
  • [1] Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO
  • [2] 2-S
  • [3] PREVALENCE AND VARIABILITY OF ORTHOSTATIC HYPOTENSION IN THE ELDERLY - RESULTS OF THE ITALIAN STUDY ON BLOOD-PRESSURE IN THE ELDERLY (SPAA)
    ALLI, C
    AVANZINI, F
    BETTELLI, G
    COLOMBO, F
    CORSO, R
    DITULLIO, M
    MARCHIOLI, R
    MARIOTTI, G
    RADICE, M
    TAIOLI, E
    TERZIAN, E
    TOGNONI, G
    ZUSSINO, A
    [J]. EUROPEAN HEART JOURNAL, 1992, 13 (02) : 178 - 182
  • [4] [Anonymous], 1951, AM J PUBLIC HEALTH
  • [5] PREVALENCE OF POSTURAL HYPOTENSION AT BASE-LINE IN THE SYSTOLIC HYPERTENSION IN THE ELDERLY PROGRAM (SHEP) COHORT
    APPLEGATE, WB
    DAVIS, BR
    BLACK, HR
    SMITH, WM
    MILLER, ST
    BURLANDO, AJ
    [J]. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 1991, 39 (11) : 1057 - 1064
  • [6] Assessment of orthostatic blood pressure: Measurement technique and clinical applications
    Carlson, JE
    [J]. SOUTHERN MEDICAL JOURNAL, 1999, 92 (02) : 167 - 173
  • [7] Chalmers J, 1999, J HYPERTENS, V17, P151
  • [8] THE ASSOCIATION OF POSTURAL CHANGES IN SYSTOLIC BLOOD-PRESSURE AND MORTALITY IN PERSONS WITH HYPERTENSION - THE HYPERTENSION DETECTION AND FOLLOW-UP PROGRAM EXPERIENCE
    DAVIS, BR
    LANGFORD, HG
    BLAUFOX, MD
    CURB, JD
    POLK, BF
    SHULMAN, NB
    [J]. CIRCULATION, 1987, 75 (02) : 340 - 346
  • [9] Orthostatic hypotension as a risk factor for stroke - The atherosclerosis risk in communities (ARIC) study, 1987-1996
    Eigenbrodt, ML
    Rose, KM
    Couper, DJ
    Arnett, DK
    Smith, R
    Jones, D
    [J]. STROKE, 2000, 31 (10) : 2307 - 2313
  • [10] Gordon T, 1959, J CHRON DIS, V10, P186