Cutting Edge: Lymphatic Vessels, Not Blood Vessels, Primarily Mediate Immune Rejections After Transplantation

被引:236
|
作者
Dietrich, Tina [1 ,2 ]
Bock, Felix [1 ,3 ]
Yuen, Don [4 ,5 ]
Hos, Deniz [1 ]
Bachmann, Bjoern O. [1 ]
Zahn, Grit [7 ]
Wiegand, Stanley [6 ]
Chen, Lu [4 ,5 ]
Cursiefen, Claus [1 ,3 ]
机构
[1] Univ Erlangen Nurnberg, Dept Ophthalmol, D-91054 Erlangen, Germany
[2] Univ Med Ctr, Dept Ophthalmol, Regensburg, Germany
[3] Harvard Univ, Sch Med, Schepens Eye Res Inst, Boston, MA 02101 USA
[4] Univ Calif Berkeley, Ctr Eye Dis & Dev, Program Vis Sci, Berkeley, CA 94701 USA
[5] Univ Calif Berkeley, Sch Optometry, Berkeley, CA 94701 USA
[6] Regeneron Pharmaceut Inc, Tarrytown, NY 10591 USA
[7] Jerini AG, Berlin, Germany
来源
JOURNAL OF IMMUNOLOGY | 2010年 / 184卷 / 02期
基金
美国国家卫生研究院;
关键词
ORTHOTOPIC CORNEAL ALLOGRAFTS; INHIBITS LYMPHANGIOGENESIS; ANTERIOR-CHAMBER; GRAFT-REJECTION; RISK-FACTORS; MICE; BLOCKADE; NEOVASCULARIZATION; NEOANGIOGENESIS; HEMANGIOGENESIS;
D O I
10.4049/jimmunol.0903180
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The purpose of this study was to determine the relative importance of blood vessels (hemangiogenesis) versus lymphatic vessels (lymphangiogenesis) in mediating immunological responses after transplantation. Using the murine model of corneal transplantation, graft survival was compared in differentially prevascularized and avascular recipient beds. Donor corneas (C57BL/6) were transplanted into uninflamed or inflamed avascular, prehemvascularized only or prehemvascularized and prelymphvascularized recipient murine eyes (BALB/C). Selective inhibition of lymphangiogenesis was achieved using antivascular endothelial growth factor receptor 3 Abs and anti-integrin alpha 5 small molecules. Grafts placed into only prehemvascularized recipient beds had a similarly good graft survival compared with grafts placed,into completely avascular, normal recipients, whereas the pre-existence of lymphatic vessels significantly deteriorated corneal graft survival (p < 0.05). Lymphatic vessels seem to contribute significantly to graft rejection after (corneal) transplantation. That may allow for selective, temporary, perioperative antilymphangiogenic treatment to promote graft survival without affecting blood vessels, even after solid organ transplantation. The Journal of Immunology, 2010, 184:535-539.
引用
收藏
页码:535 / 539
页数:5
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