Structural insights into the molecular mechanism of Ca2+-dependent exocytosis

被引：78

作者：

Brunger, AT ^{[1
]}

机构：

[1] Yale Univ, Howard Hughes Med Inst, New Haven, CT 06520 USA

[2] Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT 06520 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2000年 / 10卷 / 03期

关键词：

D O I：

10.1016/S0959-4388(00)00098-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The fusion of vesicles with target membranes is controlled by a complex network of protein-protein and protein-lipid interactions. Recent structures of the SNARE complex, synaptotagmin III, nSec1, domains of NSF and its adaptor SNAP, along with Rab3 and some of its effecters, provide the framework for developing molecular models of vesicle fusion and for designing experiments to test these models. Ultimately, this knowledge of the structures of higher-order complexes and their dynamic behavior will allow us to obtain a full understanding of the vesicle fusion protein machinery.

引用

页码：293 / 302

页数：10

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